GP9

Description		glycoprotein IX platelet
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GO Annotations	Cellular Component	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding
	Biological Process	Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Quinine
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Novel Interacting Genes		1 novel interacting genes: RAB7A
Interacting Genes		5 interacting genes: APPBP2 GP1BA GP1BB HOXA1 SPRY2
Entrez ID		2815
HPRD ID		01432
Ensembl ID		ENSG00000169704
Uniprot IDs		P14770
PDB IDs		3REZ 8WFS
Enriched GO Terms of Interacting Partners?		Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Platelet Activation Negative Regulation Of Sequestering Of Calcium Ion Platelet Activation Myeloid Cell Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Semicircular Canal Formation Synaptic Vesicle Recycling Via Endosome Calcium Ion Transmembrane Import Into Cytosol Coagulation Blood Coagulation Hemostasis Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lung Growth Regulation Of Sequestering Of Calcium Ion Sensory Perception Of Sound Lipophagy Sensory Perception Of Mechanical Stimulus Negative Regulation Of Exosomal Secretion Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Hemopoiesis Thrombin-activated Receptor Activity Protein To Membrane Docking Regulation Of Endosome Organization Ubiquitin-protein Transferase Inhibitor Activity Calcium Ion Transmembrane Transport Alveolar Lamellar Body Microtubule End Phagosome Acidification Bud Elongation Involved In Lung Branching Embryonic Neurocranium Morphogenesis Presynaptic Endosome Regulation Of Lens Fiber Cell Differentiation Respiratory System Development Calcium Ion Transport Outer Ear Morphogenesis Establishment Of Organelle Localization Retromer Complex Binding Thrombin-activated Receptor Signaling Pathway
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