GP9 and GP1BB

Number of citations of the paper that reports this interaction (PubMedID 12036872)
0

Data Source:
HPRD (in vivo)

		GP9	GP1BB
Description		glycoprotein IX platelet	glycoprotein Ib platelet subunit beta
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GO Annotations	Cellular Component	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex	Plasma Membrane Membrane Glycoprotein Ib-IX-V Complex
	Molecular Function	Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Cell Adhesion Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol	Cell Adhesion Cell Surface Receptor Signaling Pathway Blood Coagulation Blood Coagulation, Intrinsic Pathway Hemostasis Positive Regulation Of Platelet Activation Platelet Activation Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol
Pathways		Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V	Intrinsic Pathway of Fibrin Clot Formation GP1b-IX-V activation signalling Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Defective F9 activation Enhanced binding of GP1BA variant to VWF multimer:collagen Defective binding of VWF variant to GPIb:IX:V
Drugs		Quinine
Diseases		Bernard-Soulier syndrome; Giant platelet syndrome	Bernard-Soulier syndrome; Giant platelet syndrome
GWAS		Mean platelet volume ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	DNA methylation (parent-of-origin) ( 23725790) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		5 interacting genes: APPBP2 GP1BA GP1BB HOXA1 SPRY2	4 interacting genes: GP9 PRKACA TGFB1I1 YWHAZ
Entrez ID		2815	2812
HPRD ID		01432	00729
Ensembl ID		ENSG00000169704	ENSG00000203618
Uniprot IDs		P14770	P13224
PDB IDs		3REZ 8WFS	3REZ 3RFE 8WFS
Enriched GO Terms of Interacting Partners?		Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Protein Activation Cascade Megakaryocyte Development Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Platelet Activation Negative Regulation Of Sequestering Of Calcium Ion Platelet Activation Myeloid Cell Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Semicircular Canal Formation Synaptic Vesicle Recycling Via Endosome Calcium Ion Transmembrane Import Into Cytosol Coagulation Blood Coagulation Hemostasis Abducens Nerve Formation Optokinetic Behavior Negative Regulation Of Intralumenal Vesicle Formation Epidermal Growth Factor Catabolic Process Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Lung Growth Regulation Of Sequestering Of Calcium Ion Sensory Perception Of Sound Lipophagy Sensory Perception Of Mechanical Stimulus Negative Regulation Of Exosomal Secretion Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Lens Fiber Cell Differentiation Hemopoiesis Thrombin-activated Receptor Activity Protein To Membrane Docking Regulation Of Endosome Organization Ubiquitin-protein Transferase Inhibitor Activity Calcium Ion Transmembrane Transport Alveolar Lamellar Body Microtubule End Phagosome Acidification Bud Elongation Involved In Lung Branching Embryonic Neurocranium Morphogenesis Presynaptic Endosome Regulation Of Lens Fiber Cell Differentiation Respiratory System Development Calcium Ion Transport Outer Ear Morphogenesis Establishment Of Organelle Localization Retromer Complex Binding Thrombin-activated Receptor Signaling Pathway	Negative Regulation Of TOR Signaling TOR Signaling Negative Regulation Of TORC1 Signaling Regulation Of TORC1 Signaling TORC1 Signaling Regulation Of Sequestering Of Calcium Ion Tube Formation Synaptic Target Recognition Inner Ear Auditory Receptor Cell Differentiation Hair Cell Differentiation Positive Regulation Of Signal Transduction Regulation Of Cell Communication Inner Ear Receptor Cell Differentiation Regulation Of Signal Transduction Mechanoreceptor Differentiation Positive Regulation Of Immune Response To Tumor Cell Cellular Developmental Process Pyroptotic Cell Death Wide Pore Channel Activity Granzyme-mediated Programmed Cell Death Signaling Pathway Cardiolipin Binding Epithelial Cell Differentiation Regulation Of Signaling Developmental Process System Process Protein Activation Cascade Glycoprotein Ib-IX-V Complex Blood Coagulation, Intrinsic Pathway Positive Regulation Of Platelet Activation Megakaryocyte Development Regulation Of Body Fluid Levels CAMP-dependent Protein Kinase Complex Protein-lipid Complex Assembly Vascular Endothelial Cell Response To Fluid Shear Stress Response To Nutrient Levels Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Glycolytic Process Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Cellular Response To Glucagon Stimulus Ubiquitin Protein Ligase Binding Negative Regulation Of Interleukin-2 Production Response To Laminar Fluid Shear Stress Sperm Capacitation Protein Domain Specific Binding CAMP-dependent Protein Kinase Activity Interleukin-2-mediated Signaling Pathway Protein Phosphorylation Calcium Channel Complex Regulation Of Proteolysis Cellular Response To Laminar Fluid Shear Stress
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