GNG3 and GNB2

Number of citations of the paper that reports this interaction (PMID 8636150)
15

Data Source:
HPRD (two hybrid)

		GNG3	GNB2
Gene Name		guanine nucleotide binding protein (G protein), gamma 3	guanine nucleotide binding protein (G protein), beta polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Extracellular Space Lysosomal Membrane Plasma Membrane Focal Adhesion Membrane Vesicle Protein Complex Cell Body Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Signal Transducer Activity Type 1 Angiotensin Receptor Binding	GTPase Activity Signal Transducer Activity Calcium Channel Regulator Activity Protein Binding Protein Complex Binding GTPase Binding
	Biological Process	Activation Of MAPK Activity Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus	Energy Reserve Metabolic Process G-protein Coupled Receptor Signaling Pathway Synaptic Transmission Small Molecule Metabolic Process Cellular Response To Glucagon Stimulus
Pathways		Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation	Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Glucagon-type ligand receptors G beta:gamma signalling through PLC beta Signaling by Wnt Metabolic disorders of biological oxidation enzymes G protein gated Potassium channels Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 Glucagon signaling in metabolic regulation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Inwardly rectifying K+ channels G-protein beta:gamma signalling Opioid Signalling Activation of Kainate Receptors upon glutamate binding Aquaporin-mediated transport Adrenaline,noradrenaline inhibits insulin secretion G alpha (q) signalling events GPCR downstream signaling Platelet homeostasis Platelet activation, signaling and aggregation Transmission across Chemical Synapses G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signal amplification Potassium Channels G beta:gamma signalling through PI3Kgamma G alpha (12/13) signalling events Class B/2 (Secretin family receptors) Prostacyclin signalling through prostacyclin receptor GABA B receptor activation GABA receptor activation Activation of G protein gated Potassium channels Vasopressin regulates renal water homeostasis via Aquaporins Regulation of insulin secretion GPCR ligand binding beta-catenin independent WNT signaling Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Ca2+ pathway G-protein activation
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: GNB1 GNB2 GNB3 GNB4 GNB5	31 interactors: ANXA7 ATXN10 CAPNS1 CDKN1A CSNK1A1 FAM118B FANCA GADD45A GNAI1 GNAI2 GNAI3 GNG10 GNG12 GNG13 GNG3 GNG4 GNG5 GNG7 GNGT1 GRB7 GSK3B ID3 NR3C1 PCBP1 PDHB RAF1 RASD2 RCC1 STAT5A TGFBR1 TSC22D1
Entrez ID		2785	2783
HPRD ID		12337	11820
Ensembl ID		ENSG00000162188	ENSG00000172354
Uniprot IDs		P63215	P62879 Q6FHM2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Glucagon Stimulus Response To Glucagon Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Generation Of Precursor Metabolites And Energy Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Hormone Stimulus Response To Organonitrogen Compound Regulation Of Rhodopsin Mediated Signaling Pathway Response To Hormone Rhodopsin Mediated Signaling Pathway G-protein Coupled Receptor Signaling Pathway Oxidation-reduction Process Phototransduction, Visible Light Detection Of Visible Light Synaptic Transmission Cellular Response To Light Stimulus Phototransduction Cellular Response To Organic Substance Detection Of Light Stimulus Cellular Response To Radiation Small Molecule Metabolic Process Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Abiotic Stimulus Cell-cell Signaling Signal Transduction Response To Organic Substance Signaling Cell Communication Negative Regulation Of Voltage-gated Calcium Channel Activity Cardiac Muscle Cell Apoptotic Process Cell Surface Receptor Signaling Pathway Muscle Cell Apoptotic Process Cellular Response To Stimulus Response To Light Stimulus Cellular Response To Prostaglandin E Stimulus G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Response To Radiation Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Negative Regulation Of Cation Channel Activity Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Detection Of Stimulus	Cellular Response To Glucagon Stimulus Response To Glucagon Synaptic Transmission Energy Reserve Metabolic Process Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Peptide Hormone Stimulus Response To Peptide Hormone Cellular Response To Peptide Response To Peptide Cell-cell Signaling Response To Hormone Cellular Response To Hormone Stimulus Generation Of Precursor Metabolites And Energy Cell Surface Receptor Signaling Pathway Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Signal Transduction Response To Organic Substance G-protein Coupled Receptor Signaling Pathway Signaling Cellular Response To Organic Substance Cell Communication Cellular Response To Stimulus Response To Stimulus Regulation Of Cellular Process Regulation Of Adenylate Cyclase Activity Regulation Of Cyclase Activity Regulation Of Signal Transduction Cell Cycle Regulation Of CAMP Biosynthetic Process Regulation Of Body Fluid Levels Regulation Of Signaling Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of CAMP Metabolic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Hemostasis Positive Regulation Of Signal Transduction Response To Wounding Positive Regulation Of Protein Kinase Activity Activation Of Protein Kinase Activity Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Kinase Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires slc27a1 slc27a2 solute wagyu wagyuxangus weinberg	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Difference) ?		1n9 angus asb3 backfat corticotropin crossbreeding dermatan desaturase dsel efemp1 epimerase fibulin hardy healthful heterosis linolenic marbling oleic overdominant palmitic parentage pltp sires slc27a1 slc27a2 solute wagyu wagyuxangus weinberg	abl alterations bcr bez235 braf canonical cdkn2a clustered coexpression confer dimer disrupt effectors encoding galpha gbeta gbetagamma gnb1 i80 interface k57 neoplasms oncogenic partly substitution subunits targetable v600k variants
Tagcloud (Intersection) ?