GNG3 and TRIM73

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GNG3	TRIM73
Description		G protein subunit gamma 3	tripartite motif containing 73
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Body Synapse	Cytoplasm Cytosol
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Zinc Ion Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration	Innate Immune Response
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		8 interacting genes: GNB1 GNB2 GNB3 GNB4 GNB5 NTAQ1 SS18L2 TRIM73	18 interacting genes: ARID5A BEX2 C9orf72 DDIT4L FHL2 GNG3 HGS KRT34 NTAQ1 OIP5 PNMA1 POU6F2 PRR35 PSMF1 RUSC1 TASOR2 TTC23 YPEL3
Entrez ID		2785	375593
HPRD ID		12337	18606
Ensembl ID		ENSG00000162188	ENSG00000178809
Uniprot IDs		P63215	Q86UV7
PDB IDs
Enriched GO Terms of Interacting Partners?		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Protein-containing Complex Binding Lysosomal Membrane Synapse GTPase Activator Complex G-protein Gamma-subunit Binding Protein-N-terminal Glutamine Amidohydrolase Activity Dark Adaptation Protein-N-terminal Asparagine Amidohydrolase Activity Light Adaption Cytosol Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
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