GNG3 and SS18L2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		GNG3	SS18L2
Name		G protein subunit gamma 3	SS18 like 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Postsynaptic Density Membrane Dendrite Cell Body Synapse	None
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration	None
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	None
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: PBRM1
Interacting Genes		8 interacting genes: GNB1 GNB2 GNB3 GNB4 GNB5 NTAQ1 SS18L2 TRIM73	6 interacting genes: EMC2 FBXO7 GNG3 LYPD6 MBD5 TMEM17
Entrez ID		2785	51188
HPRD ID		12337	09399
Ensembl ID		ENSG00000162188	ENSG00000008324
Uniprot IDs		P63215	Q9UHA2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Signaling Receptor Complex Adaptor Activity Heterotrimeric G-protein Complex GTPase Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway G Protein-coupled Dopamine Receptor Signaling Pathway Protein-containing Complex Binding Lysosomal Membrane Synapse GTPase Activator Complex G-protein Gamma-subunit Binding Protein-N-terminal Glutamine Amidohydrolase Activity Dark Adaptation Protein-N-terminal Asparagine Amidohydrolase Activity Light Adaption Cytosol Regulation Of Locomotion Involved In Locomotory Behavior Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway	Extrinsic Component Of Endoplasmic Reticulum Membrane Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Hippocampal Interneuron Differentiation Lewy Body Core Positive Regulation Of Growth Hormone Receptor Signaling Pathway