SKI

Name	SKI proto-oncogene
Structure
Interactors	20 interactors: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Nuclear Body PML Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding SMAD Binding Histone Deacetylase Inhibitor Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Regulation Of Neurogenesis Roof Of Mouth Development Cardiac Muscle Cell Proliferation Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis Negative Regulation Of SMAD Protein Signal Transduction Muscle Structure Development
Pathways	Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
GWAS	Alanine aminotransferase levels ( 33547301 ) Appendicular lean mass ( 33097823 ) Body mass index ( 26426971 ) Coronary artery disease ( 29212778 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Myocardial infarction ( 33532862 ) Platelet count ( 32888494 ) Platelet distribution width ( 27863252 32888494 ) Plateletcrit ( 32888494 ) PR interval ( 30046033 32439900 ) Systolic blood pressure ( 30224653 ) Urate levels ( 31578528 )
Entrez ID	6497
HPRD ID	01271
Ensembl ID	ENSG00000157933
Uniprot IDs	P12755
PDB IDs	1MR1 1SBX 5XOD 6ZVQ
GO Terms Enriched among Interactors ?	Negative Regulation Of RNA Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process SMAD Protein Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Developmental Process Positive Regulation Of DNA-templated Transcription Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression I-SMAD Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Multicellular Organismal Development RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of MiRNA Transcription Chromatin Binding Cellular Developmental Process SMAD Protein Complex Regulation Of Cell Differentiation Negative Regulation Of Developmental Process Regulation Of Developmental Process Regulation Of Multicellular Organismal Process Cell Surface Receptor Signaling Pathway Cell Population Proliferation