SGSM3 and NF2

Number of citations of the paper that reports this interaction (PMID 15541357)
0

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SGSM3	NF2
Gene Name		small G protein signaling modulator 3	neurofibromin 2 (merlin)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol	Nucleus Nucleolus Cytoplasm Early Endosome Cytoskeleton Plasma Membrane Adherens Junction Membrane Extrinsic Component Of Membrane Lamellipodium Cortical Actin Cytoskeleton Filopodium Membrane Cleavage Furrow Ruffle Membrane Apical Part Of Cell Perinuclear Region Of Cytoplasm
	Molecular Function	Rab GTPase Activator Activity Protein Binding Rab GTPase Binding	Actin Binding Protein Binding
	Biological Process	Cell Cycle Arrest Regulation Of Rab Protein Signal Transduction Rap Protein Signal Transduction Positive Regulation Of Rab GTPase Activity Plasma Membrane To Endosome Transport Regulation Of Cilium Assembly	Mesoderm Formation Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Protein Kinase Activity Ectoderm Development Negative Regulation Of DNA Replication Negative Regulation Of Cell Proliferation Schwann Cell Proliferation Hippocampus Development Negative Regulation Of Cell-cell Adhesion Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Regulation Of Protein Stability Regulation Of Hippo Signaling Odontogenesis Of Dentin-containing Tooth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Negative Regulation Of MAPK Cascade Cell-cell Junction Organization Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Positive Regulation Of Stress Fiber Assembly Lens Fiber Cell Differentiation Regulation Of Protein Localization To Nucleus Regulation Of Neural Precursor Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Height ( 19570815)	Carotid atherosclerosis in HIV infection ( 20009918)
Protein-Protein Interactions		7 interactors: GJA1 NF2 RAB39B RAB5A RAB5B RAB5C RPL35	24 interactors: AGAP2 AKT1 CCNB1IP1 CD44 CTNNB1 ERBB2 EZR HGS ITGB1 KDM1A MED28 PAK1 PXN PYGO2 RALGDS SCHIP1 SDCBP SGSM3 SLC9A3R1 SPTBN1 TARBP2 TSC1 VPRBP XPO1
Entrez ID		27352	4771
HPRD ID		15285	06980
Ensembl ID		ENSG00000100359	ENSG00000186575
Uniprot IDs		B4DMS2 B4DVE3 B9A6J5 Q96HU1	P35240
PDB IDs			1H4R 3U8Z
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Ras Protein Signal Transduction Plasma Membrane To Endosome Transport Intracellular Protein Transport Cellular Protein Localization Protein Transport Small GTPase Mediated Signal Transduction Regulation Of Endocytosis Establishment Of Protein Localization Intracellular Transport Endosomal Transport Cytoplasmic Transport Protein Localization Regulation Of Cellular Component Organization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Cellular Localization Milk Ejection Vascular Transport Lens Development In Camera-type Eye Negative Regulation Of DNA Metabolic Process Vesicle-mediated Transport Transport Atrial Ventricular Junction Remodeling Positive Regulation Of Cell Communication By Chemical Coupling Regulation Of Cellular Component Movement Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Intracellular Signal Transduction Cell Communication By Chemical Coupling Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Cell-cell Junction Organization ATP Transport Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Positive Regulation Of Glomerular Filtration Schwann Cell Proliferation Positive Regulation Of Behavioral Fear Response Adenine Nucleotide Transport Regulation Of Hippo Signaling Regulation Of Cellular Localization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Atrial Cardiac Muscle Cell Action Potential Purine Nucleotide Transport Atrial Cardiac Muscle Cell To AV Node Cell Communication Regulation Of Tight Junction Assembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Secretion Regulation Of Glomerular Filtration Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization	Regulation Of Intracellular Signal Transduction Regulation Of Protein Metabolic Process Cell Development Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Cell Projection Organization Regulation Of Cellular Component Organization Enzyme Linked Receptor Protein Signaling Pathway Cell Differentiation Regulation Of Cellular Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Proliferation Positive Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Growth Factor Axon Guidance Negative Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Signal Transduction Anatomical Structure Development Positive Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Protein Localization Regulation Of Protein Kinase Activity Cell Morphogenesis Cell-matrix Adhesion Signal Transduction Nervous System Development Axonogenesis Cellular Response To Organic Substance Regulation Of Kinase Activity Movement Of Cell Or Subcellular Component Protein Localization Regulation Of Catalytic Activity Multicellular Organismal Development Developmental Process Cellular Localization Anatomical Structure Morphogenesis Axon Development Response To Stimulus Cellular Response To Growth Factor Stimulus
Tagcloud ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a tumorigenic unchanged wbp2 wbp2nl ww wwox wwp1 wwtr1 yap1 yes	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Difference) ?		athanogene bag3 bcl2 cancerous developmentally e3 fnbp4 formin guanylatekinase ligase magi1 modulator nedd4 oncogene oncogenic oxidoreductase pdz property rab2a tumorigenic unchanged wbp2 wbp2nl ww wwox wwp1 wwtr1 yap1 yes	22q allele alleles analysed assumed candidates carcinomas colorectal coupled cys digestive e1a gastric gene heterozygosity inactivation located missense mutation neurofibromatosis p300 participates rich sequencing somatic sscp suppressor though thought
Tagcloud (Intersection) ?