SGSM3 and RAB39B

Number of citations of the paper that reports this interaction (PubMedID 16923123)
0

Data Source:
BioGRID (two hybrid)

		SGSM3	RAB39B
Description		small G protein signaling modulator 3	RAB39B, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Gap Junction	Autophagosome Membrane Lysosome Golgi Apparatus Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Vesicle Neuron Projection Autolysosome Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Small GTPase Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Myosin V Binding Metal Ion Binding
	Biological Process	Endosomal Transport Regulation Of Endocytosis Regulation Of Rab Protein Signal Transduction Rap Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Catabolic Process Plasma Membrane To Endosome Transport Regulation Of Cell Cycle Regulation Of Cilium Assembly	Autophagy Regulation Of Autophagy Protein Transport Vesicle-mediated Transport Rab Protein Signal Transduction Synapse Organization
Pathways			RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Body mass index ( 26426971) Breast size ( 29855537) Chronotype ( 27494321) Height ( 19570815) Mammographic density (dense area) ( 25342443) Morning vs. evening chronotype ( 27494321) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		10 interacting genes: CHRM3 DSCAM FMO3 GJA1 NF2 RAB39B RAB5A RAB5B RAB5C RPL35	6 interacting genes: GOLGA2 RAB3GAP1 RUFY1 SGSM3 VPS26C ZDHHC17
Entrez ID		27352	116442
HPRD ID		15285	06703
Ensembl ID		ENSG00000100359	ENSG00000155961
Uniprot IDs		B4DVE3 B9A6J5 Q96HU1	Q96DA2
PDB IDs			6S5F
Enriched GO Terms of Interacting Partners?		Plasma Membrane To Endosome Transport G Protein Activity GDP Binding Endocytic Vesicle Early Endosome GTPase Activity Melanosome GTP Binding Regulation Of Transport Membrane Cell Junction Organization Regulation Of Vesicle-mediated Transport Early Endosome Membrane Endomembrane System Endosomal Transport Plasma Membrane Albendazole Monooxygenase Activity Post-embryonic Retina Morphogenesis In Camera-type Eye Regulation Of Cellular Component Organization Netrin Receptor Binding Trimethylamine Monooxygenase Activity Hypotaurine Monooxygenase Activity Regulation Of Stem Cell Proliferation Endosome Organization Positive Regulation Of Mesodermal Cell Differentiation Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Schwann Cell Proliferation Ruffle Protein Localization To Early Endosome Intracellular Protein Localization Endocytosis Dendrite N,N-dimethylaniline Monooxygenase Activity Taurine Biosynthetic Process Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Cytoplasmic Side Of Early Endosome Membrane Protein Transport Synaptic Vesicle Membrane G Protein-coupled Acetylcholine Receptor Activity Gap Junction Hemi-channel Activity Vesicle-mediated Transport Intracellular Protein Transport Saliva Secretion Positive Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Secretion By Cell Acetylcholine Binding Cell-cell Signaling Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway	Establishment Of Protein Localization Cellular Localization Endosomal Transport Small GTPase-mediated Signal Transduction Cis-Golgi Network Protein Transport Vesicle-mediated Transport Intracellular Transport Perforant Pathway To Dendrate Granule Cell Synapse Positive Regulation Of GTPase Activity Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Positive Regulation Of Hydrolase Activity Regulation Of Vesicle-mediated Transport Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Establishment Of Localization In Cell Regulation Of GTPase Activity Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Positive Regulation Of Protein Glycosylation Intracellular Protein Localization Positive Regulation Of Protein Lipidation Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Rab Protein Signal Transduction Regulation Of Endoplasmic Reticulum Tubular Network Organization Regulation Of Glutamate Secretion, Neurotransmission Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Protein Metabolic Process Golgi Disassembly Protein-cysteine S-stearoyltransferase Activity Intracellular Signaling Cassette Regulation Of Protein Glycosylation Regulation Of Protein Lipidation Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Importin-alpha Family Protein Binding Regulation Of Organelle Assembly GTPase Activator Activity Golgi Ribbon Formation Rap Protein Signal Transduction Plasma Membrane To Endosome Transport Golgi Cis Cisterna Golgi Vesicle Transport Small GTPase Binding Positive Regulation Of Glutamate Secretion Regulation Of Neurotrophin TRK Receptor Signaling Pathway Asymmetric Cell Division Positive Regulation Of Catalytic Activity Regulation Of Lipoprotein Metabolic Process Hypothalamus Development Regulation Of Short-term Neuronal Synaptic Plasticity
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