TNRC17 and SKIC2

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		TNRC17	SKIC2
Description		trinucleotide repeat containing 17	SKI2 subunit of superkiller complex
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Cytoplasm Cytosol Ski Complex
	Molecular Function		Nucleotide Binding Nucleic Acid Binding RNA Binding RNA Helicase Activity Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' RNA Helicase Activity
	Biological Process		RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay Rescue Of Stalled Ribosome
Pathways			Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease
Drugs
Diseases
GWAS
Interacting Genes		1 interacting genes: SKIC2	15 interacting genes: CACNB3 CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA PRKAA2 RHOU SNRPB TNRC17 TSSK2 WDR1 WEE2-AS1 XRN1
Entrez ID		27321	6499
HPRD ID			02724
Ensembl ID			ENSG00000204351
Uniprot IDs			A0A1U9X8J1 A0A8V8TLC0 H7C5N0 Q15477
PDB IDs			7QDR 7QDS 7QDY 7QDZ 7QE0 9G8M 9G8N 9G8O 9G8P 9G8Q 9G8R
Enriched GO Terms of Interacting Partners?		Ski Complex Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay 3'-5' RNA Helicase Activity Rescue Of Stalled Ribosome Ribosome Disassembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translational Elongation Organelle Disassembly RNA Helicase Activity Nuclear-transcribed MRNA Catabolic Process Helicase Activity MRNA Catabolic Process	Nuclear MRNA Surveillance Histone MRNA Catabolic Process Telomerase RNA Binding Histone MRNA Metabolic Process Nuclear RNA Surveillance RNA Surveillance Poly(A)-dependent SnoRNA 3'-end Processing Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Exosome (RNase Complex) Nuclear Exosome (RNase Complex) Sno(s)RNA Metabolic Process RRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process Maturation Of 5.8S RRNA U1 SnRNP Negative Regulation Of Telomere Maintenance Via Telomerase MRNA Catabolic Process Protein Serine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity 3'-5'-RNA Exonuclease Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Protein Serine/threonine Kinase Activity Regulation Of Membrane Repolarization Negative Regulation Of Telomere Maintenance Podosome Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cellular Component Organization RNA Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Establishment Of Planar Polarity Of Follicular Epithelium Cellular Response To Puromycin Cellular Response To Cycloheximide Exonuclease Activity Protein Kinase Activity SnRNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening RRNA Metabolic Process Euchromatin Regulation Of Cell Morphogenesis Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of High Voltage-gated Calcium Channel Activity Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Histone H2BS36 Kinase Activity Proline Dehydrogenase Activity
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