TCTA and SLC35A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TCTA	SLC35A1
Description		T cell leukemia translocation altered	solute carrier family 35 member A1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Golgi Membrane Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Protein Binding	CMP-N-acetylneuraminate Transmembrane Transporter Activity Protein Binding Pyrimidine Nucleotide-sugar Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Negative Regulation Of Osteoclast Differentiation Osteoclast Fusion	Carbohydrate Metabolic Process N-acetylneuraminate Metabolic Process CMP-N-acetylneuraminate Biosynthetic Process CMP-N-acetylneuraminate Transmembrane Transport Protein Modification Process Pyrimidine Nucleotide-sugar Transmembrane Transport
Pathways			Sialic acid metabolism Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) Transport of nucleotide sugars Matriglycan biosynthesis on DAG1
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type II
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Extremely high intelligence ( 29520040) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908) Metabolite levels ( 23823483) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Bone mineral density (hip) ( 30172743) Obesity-related traits ( 23251661)
Interacting Genes		7 interacting genes: ADRB2 ATXN1 BMP10 CMTM7 SLC35A1 SMAD4 YIPF6	36 interacting genes: AQP6 ARL13B ASGR2 ASZ1 BCL2L13 CD53 CERS4 CPLX4 EBAG9 ERGIC3 F11R F2RL1 FAM209A FNDC9 FXYD3 GPX8 KIR3DL3 LHFPL5 LMNA MCFD2 MGST3 MRPS18B PIK3IP1 PLPP4 PSCA RELL2 SAR1A SDC3 SLC1A1 SLC34A2 SSMEM1 SYT2 TCTA TMEM139 TMPRSS2 TMX2
Entrez ID		6988	10559
HPRD ID		15977	09290
Ensembl ID		ENSG00000145022	ENSG00000164414
Uniprot IDs		P57738	P78382
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Cell Proliferation Involved In Heart Morphogenesis Negative Regulation Of Growth Regulation Of Muscle System Process Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Activin Receptor Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Nucleobase-containing Compound Biosynthetic Process Transcription By RNA Polymerase II Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of SMAD Protein Signal Transduction Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis CMP-N-acetylneuraminate Transmembrane Transporter Activity CMP-N-acetylneuraminate Transmembrane Transport DNA-templated Transcription BMP Signaling Pathway Regulation Of Striated Muscle Cell Differentiation Beta2-adrenergic Receptor Activity Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis B-1a B Cell Differentiation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Positive Regulation Of Developmental Process Regulation Of System Process Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Metanephric Mesenchyme Morphogenesis Regulation Of Growth Regulation Of Multicellular Organismal Development Response To Psychosocial Stress Regulation Of Muscle Contraction Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Cell Growth Regulation Of Muscle Cell Differentiation Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Luteinizing Hormone Secretion Kidney Development Sulfate Binding	Membrane
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