POLR3D and HOXA10

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		POLR3D	HOXA10
Gene Name		polymerase (RNA) III (DNA directed) polypeptide D, 44kDa	homeobox A10
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm DNA-directed RNA Polymerase III Complex Cytoplasm Cytosol	Nucleus Transcription Factor Complex Cytoplasm
	Molecular Function	RNA Polymerase III Activity DNA Binding Chromatin Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Protein Binding Histone Deacetylase Binding
	Biological Process	Transcription From RNA Polymerase III Promoter Transcription Elongation From RNA Polymerase III Promoter Termination Of RNA Polymerase III Transcription Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Positive Regulation Of Innate Immune Response Defense Response To Virus	Skeletal System Development Transcription, DNA-templated Multicellular Organismal Development Spermatogenesis Single Fertilization Male Gonad Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Embryonic Limb Morphogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Uterus Development
Pathways		RNA Polymerase III Transcription Termination RNA Polymerase III Transcription RNA Polymerase III Transcription Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase III Abortive And Retractive Initiation Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Initiation From Type 2 Promoter Innate Immune System
Drugs
Diseases
GWAS		Hypertriglyceridemia ( 23505323)	Dental caries ( 23259602)
Protein-Protein Interactions		13 interactors: APEX1 ATF3 HNRNPAB HOXA10 HOXC9 MAPK11 MSX2 NR2E3 POLR3E RBFOX2 RHOXF2 TAB1 ZNF496	12 interactors: CREBBP EMX1 EP300 FOXO1 GMNN MEIS1 PBX1 POLR3D PTPN6 SIRT2 SNAPC1 SPI1
Entrez ID		661	3206
HPRD ID		01755	00845
Ensembl ID		ENSG00000168495	ENSG00000253293
Uniprot IDs		P05423	P31260
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Organ Development Developmental Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Anatomical Structure Morphogenesis Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Biosynthetic Process Anatomical Structure Development Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Anterior/posterior Pattern Specification Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Epithelial To Mesenchymal Transition Positive Regulation Of Transcription, DNA-templated Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway System Development Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Immune System Process Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Oxygen Levels Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Nitrogen Compound Metabolic Process Cell Development Protein Acetylation Negative Regulation Of Cell Differentiation N-terminal Peptidyl-lysine Acetylation Stem Cell Maintenance Positive Regulation Of Transcription, DNA-templated Innate Immune Response Organ Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Gene Expression Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Morphogenesis Gene Expression Multicellular Organismal Development Stem Cell Development Regulation Of Gene Expression Peptidyl-lysine Modification Cellular Macromolecule Biosynthetic Process Anatomical Structure Development Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Positive Regulation Of Type I Interferon Production Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Stem Cell Differentiation N-terminal Protein Amino Acid Acetylation Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune Response Developmental Process Regulation Of Type I Interferon Production Negative Regulation Of Gene Expression System Development Defense Response
Tagcloud ?		address ago1 antisense argonaute cis cytoplasm directed directs encoded existence h3k27me3 interference micrornas mir mirna mirnas orientation pcg polycomb posttranscriptional proximal rnai searched silence silencing start tgs transcriptionally tri	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting start suppresses transcriptionally way
Tagcloud (Difference) ?		address ago1 antisense argonaute cis cytoplasm directed directs encoded existence h3k27me3 interference micrornas mir mirna mirnas orientation pcg polycomb posttranscriptional proximal rnai searched silence silencing tgs tri	contrary coordination definitive drives e2 elevate epigenetic eralpha ere ere1 ere2 eres extensively h3k4 haematopoiesis homeobox knockdown leukaemia lineage methylase mll mll1 much oestrogen recruiting suppresses way
Tagcloud (Intersection) ?		start transcriptionally