DKK3 and IDH1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		DKK3	IDH1
Description		dickkopf Wnt signaling pathway inhibitor 3	isocitrate dehydrogenase (NADP(+)) 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Cytoplasm Mitochondrion Peroxisome Peroxisomal Matrix Cytosol Secretory Granule Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity	Magnesium Ion Binding Isocitrate Dehydrogenase (NADP+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Metal Ion Binding NADP Binding NAD Binding
	Biological Process	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process	Glyoxylate Cycle Tricarboxylic Acid Cycle Isocitrate Metabolic Process 2-oxoglutarate Metabolic Process NADP+ Metabolic Process NADPH Regeneration Glutathione Metabolic Process Response To Oxidative Stress Female Gonad Development Response To Steroid Hormone Regulation Of Phospholipid Catabolic Process Regulation Of Phospholipid Biosynthetic Process
Pathways			Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate NADPH regeneration Neutrophil degranulation Peroxisomal protein import Peroxisomal protein import NFE2L2 regulating TCA cycle genes
Drugs			Isocitric Acid Nicotinamide adenine dinucleotide phosphate Ivosidenib Olutasidenib
Diseases
GWAS		Blood protein levels ( 30072576) Cortical volume ( 32963231) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 34021172)	Adult diffuse glioma (IDH mutation) ( 32386320) Cerebral amyloid deposition (PET imaging) ( 30361487) Glioma ( 28346443) Non-glioblastoma glioma ( 28346443)
Interacting Genes		13 interacting genes: APC AURKA BCAR3 DYRK1A ESR2 FZR1 HOXA1 IDH1 NUFIP2 PPM1D SGTA SMAD4 UBQLN4	19 interacting genes: AGGF1 CALM1 CDK1 CRACR2B DKK3 FAM131A FHL2 FIGNL1 FILNC1 LAX1 LINC01554 NUP62 PEX5 PLK1 PRDM14 SUMO4 TMOD4 UBL7 ZHX1
Entrez ID		27122	3417
HPRD ID		05659	00984
Ensembl ID		ENSG00000050165	ENSG00000138413
Uniprot IDs		F6SYF8 Q9UBP4	A0A024R3Y6 O75874
PDB IDs			1T09 1T0L 3INM 3MAP 3MAR 3MAS 4I3K 4I3L 4KZO 4L03 4L04 4L06 4UMX 4UMY 4XRX 4XS3 5DE1 5GIR 5K10 5K11 5L57 5L58 5LGE 5SUN 5SVF 5TQH 5YFM 5YFN 6ADG 6B0Z 6BKX 6BKY 6BKZ 6BL0 6BL1 6BL2 6IO0 6O2Y 6O2Z 6PAY 6Q6F 6U4J 6VEI 6VG0 7PJM 7PJN 8BAY 8HB9 8T7D 8T7N 8T7O 8VH9 8VHA 8VHB 8VHC 8VHD 8VHE
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Nuclear Division Negative Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Female Gonad Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization DNA Damage Response Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Anterior/posterior Axis Specification Positive Regulation Of Proteolysis Negative Regulation Of Microtubule Polymerization Or Depolymerization Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Nucleus Cellular Response To Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule-based Process Protein Catabolic Process Cytosol Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Macromolecule Metabolic Process Centrosome Intracellular Signal Transduction	Spindle Microtubule Cell Cycle G2/M Phase Transition G2/M Transition Of Mitotic Cell Cycle Centrosome Cycle Ventricular Cardiac Muscle Cell Development Mitotic Nuclear Membrane Disassembly Centrosome Separation Regulation Of Cytokinesis Nuclear Membrane Disassembly Microtubule Organizing Center Organization Membrane Disassembly Protein Localization To Site Of Double-strand Break Mitotic Cell Cycle Phase Transition Regulation Of Cell Division Spindle Pole Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Pronuclear Fusion Cardiac Muscle Cell Development Chromosome Condensation Cardiac Cell Development Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Organization SH2 Domain Binding Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Methyltransferase Regulator Activity Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Spindle Negative Regulation Of Apoptotic Process Mitotic DNA-templated DNA Replication Post-translational Protein Modification Nuclear Membrane Organization Cellular Response To Oxidative Stress Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Mitotic G2/M Transition Checkpoint Cyclin A2-CDK1 Complex Hsp70 Protein Binding Negative Regulation Of DNA-templated Transcription Atrial Cardiac Muscle Cell Development Negative Regulation Of RNA Biosynthetic Process Synaptonemal Complex Disassembly Golgi Inheritance Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Negative Regulation Of Programmed Cell Death Mitotic DNA Damage Checkpoint Signaling Negative Regulation Of Cell Cycle G2/M Phase Transition Cellular Response To Chemical Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?