DKK3 and FZR1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		DKK3	FZR1
Description		dickkopf Wnt signaling pathway inhibitor 3	fizzy and cell division cycle 20 related 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Co-receptor Binding Receptor Antagonist Activity	Protein Binding Anaphase-promoting Complex Binding Ubiquitin-protein Transferase Activator Activity Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Anatomical Structure Morphogenesis Wnt Signaling Pathway Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Adrenal Gland Development Negative Regulation Of Aldosterone Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anti-Mullerian Hormone Signaling Pathway Negative Regulation Of Cortisol Biosynthetic Process	DNA Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Population Proliferation Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Thymidine Biosynthetic Process Cell Division Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity DNA Synthesis Involved In Mitotic DNA Replication Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of Cellular Senescence
Pathways			Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cortical volume ( 32963231) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933) Response to perphenazine in schizophrenia ( 29503163) Response to taxane treatment (docetaxel) ( 23006423) Visceral fat ( 22589738) Waist circumference adjusted for body mass index ( 34021172)	Red cell distribution width ( 32888494)
Interacting Genes		13 interacting genes: APC AURKA BCAR3 DYRK1A ESR2 FZR1 HOXA1 IDH1 NUFIP2 PPM1D SGTA SMAD4 UBQLN4	95 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC7 ANLN ARNT BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNA1 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L DTYMK E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A ID2 KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RB1 RBBP8 SASS6 SENP2 SIRT1 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TBK1 TEAD2 TERT THRSP TK1 TTF2 UBC UBE2D1 UBE2D3 UBE2K UHRF1 USP10
Entrez ID		27122	51343
HPRD ID		05659	04687
Ensembl ID		ENSG00000050165	ENSG00000105325
Uniprot IDs		F6SYF8 Q9UBP4	Q9UM11
PDB IDs			4UI9 5L9T 5L9U 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nucleoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Response To Stress Positive Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Regulation Of Nuclear Division Negative Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteolysis Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Female Gonad Development Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization DNA Damage Response Protein Serine/threonine/tyrosine Kinase Activity Negative Regulation Of Metabolic Process Proteasomal Protein Catabolic Process Regulation Of Metabolic Process Anterior/posterior Axis Specification Positive Regulation Of Proteolysis Negative Regulation Of Microtubule Polymerization Or Depolymerization Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Nucleus Cellular Response To Stress Positive Regulation Of Catabolic Process Ubiquitin-dependent Protein Catabolic Process Histone H3T45 Kinase Activity Semicircular Canal Formation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis G2/M Transition Of Mitotic Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Microtubule-based Process Protein Catabolic Process Cytosol Regulation Of Cellular Component Organization Identical Protein Binding Regulation Of Macromolecule Metabolic Process Centrosome Intracellular Signal Transduction	Regulation Of Cell Cycle Regulation Of Cell Cycle Process Cell Division Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Nucleoplasm G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Nucleus Regulation Of Primary Metabolic Process Cytoplasm Regulation Of Chromosome Segregation Cytosol Regulation Of Chromosome Organization Regulation Of Sister Chromatid Segregation Regulation Of Metabolic Process Regulation Of Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Protein Modification Process Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Kinase Activity Positive Regulation Of Cell Cycle Phase Transition Spindle Protein Kinase Activity Regulation Of Organelle Organization Negative Regulation Of Metabolic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cell Cycle Process Post-translational Protein Modification Negative Regulation Of Macromolecule Metabolic Process Modification-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Cell Population Proliferation Cellular Response To Stress Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Transferase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process
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