UQCRQ and POLR2M

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UQCRQ	POLR2M
Description		ubiquinol-cytochrome c reductase complex III subunit VII	RNA polymerase II subunit M
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III	DNA-directed RNA Polymerase Complex Nucleus Nuclear Envelope RNA Polymerase II, Core Complex I Band Neuronal Cell Body Transcription Preinitiation Complex
	Molecular Function		RNA Polymerase II Complex Binding Transcription Elongation Factor Activity
	Biological Process	Mitochondrial Electron Transport, Ubiquinol To Cytochrome C Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Midbrain Development Cellular Respiration	Transcription Elongation By RNA Polymerase II Maintenance Of ER Location
Pathways		Respiratory electron transport Mitochondrial protein degradation Complex III assembly Complex III assembly
Drugs		2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol 6-Hydroxy-5-undecyl-4,7-benzothiazoledione Azoxystrobin (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE (S)-famoxadone METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE 2-Nonyl-4-quinolinol 1-oxide Ubiquinone Q2
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Asthma ( 31619474)	Body mass index ( 28552196) Seasonality ( 25562672)
Interacting Genes		5 interacting genes: ERCC6 ERCC8 OPTN POLR2M UBC	22 interacting genes: AHSP ANKHD1 APOD CEBPG CEP126 DAPK1 DGKZ HIGD1B LRRK1 LRRK2 MYO3A MYO9A NEDD4 PSMC2 RBM4B RPL7A SCMH1 SIVA1 THAP1 UQCRQ WDR89 ZNF410
Entrez ID		27089	81488
HPRD ID		17941	07575
Ensembl ID		ENSG00000164405	ENSG00000255529
Uniprot IDs		O14949	P0CAP2 Q6EEV4
PDB IDs		5XTE 5XTH 5XTI	6DRD
Enriched GO Terms of Interacting Partners?		Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Protein Ubiquitination Response To X-ray Protein Modification By Small Protein Conjugation Post-translational Protein Modification Site Of DNA Damage Nucleotide-excision Repair DNA-templated Transcription Elongation Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription-coupled Nucleotide-excision Repair Maintenance Of ER Location Regulation Of DNA Metabolic Process Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Protein Modification Process Positive Regulation Of DNA Repair Response To Ionizing Radiation Response To UV Negative Regulation Of Receptor Recycling Type 2 Mitophagy Double-strand Break Repair Nucleotide-excision Repair Complex Regulation Of DNA Repair B-WICH Complex DNA Protection Transcription Elongation By RNA Polymerase I Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Response To Superoxide Response To Oxygen Radical Positive Regulation Of Xenophagy Histone H4K16 Acetyltransferase Activity Endoplasmic Reticulum Localization Transcription Elongation Factor Activity Nucleoplasm Pyrimidine Dimer Repair Golgi Ribbon Formation Histone H3K14 Acetyltransferase Activity Positive Regulation Of DNA Metabolic Process Histone H4K5 Acetyltransferase Activity Histone H4K8 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Transcription Preinitiation Complex Cul4A-RING E3 Ubiquitin Ligase Complex Response To Light Stimulus Protein Tag Activity Protein Tyrosine Kinase Activator Activity Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase III ATP-dependent DNA Damage Sensor Activity
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