UQCRQ and ERCC8

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		UQCRQ	ERCC8
Gene Name		ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa	excision repair cross-complementation group 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Respiratory Chain	Nucleotide-excision Repair Complex Nucleus Nucleoplasm Nuclear Matrix Cul4A-RING E3 Ubiquitin Ligase Complex Protein Complex
	Molecular Function	Ubiquinol-cytochrome-c Reductase Activity	DNA Helicase Activity Ubiquitin-protein Transferase Activity Protein Binding DNA-dependent ATPase Activity Protein Complex Binding
	Biological Process	Subthalamus Development Pons Development Cerebellar Purkinje Cell Layer Development Hippocampus Development Thalamus Development Hypothalamus Development Pyramidal Neuron Development Respiratory Electron Transport Chain Midbrain Development Cellular Metabolic Process Small Molecule Metabolic Process Hydrogen Ion Transmembrane Transport	Protein Polyubiquitination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Response To UV Response To X-ray Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Repair Protein Autoubiquitination
Pathways		Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. Respiratory electron transport The citric acid (TCA) cycle and respiratory electron transport	Nucleotide Excision Repair Transcription-coupled NER (TC-NER) Formation of transcription-coupled NER (TC-NER) repair complex Dual incision reaction in TC-NER
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ERCC8 OPTN POLR2M	8 interactors: CBR1 CSNK2B DDB1 ERCC6 GTF2H2 TOP1 UQCRQ XAB2
Entrez ID		27089	1161
HPRD ID		17941	07523
Ensembl ID			ENSG00000049167
Uniprot IDs		O14949	B4DGZ9 Q13216
PDB IDs			4A11
Enriched GO Terms of Interacting Partners?		Maintenance Of ER Location Endoplasmic Reticulum Localization Negative Regulation Of Receptor Recycling Golgi Ribbon Formation Protein Targeting To Golgi Golgi To Plasma Membrane Protein Transport Establishment Of Protein Localization To Golgi Retrograde Transport, Vesicle Recycling Within Golgi Regulation Of Receptor Recycling Response To X-ray Golgi To Plasma Membrane Transport Positive Regulation Of DNA Repair Defense Response To Gram-negative Bacterium Transcription-coupled Nucleotide-excision Repair Protein Localization To Golgi Apparatus Protein Autoubiquitination	Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair DNA Metabolic Process Response To UV Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription Elongation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Cellular Response To DNA Damage Stimulus Response To Light Stimulus Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Radiation Viral Process Subthalamus Development Cellular Response To Stress DNA Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Regulation Of Viral Process Cellular Metabolic Process Phosphorylation UV-damage Excision Repair Vitamin K Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Viral Release From Host Cell Adiponectin-activated Signaling Pathway Activation Of JNKK Activity Wnt Signaling Pathway Endothelial Tube Morphogenesis Pyramidal Neuron Development Pons Development Histone H2A Monoubiquitination Pyramidal Neuron Differentiation Embryonic Cleavage Pyrimidine Dimer Repair G-protein Coupled Receptor Internalization Response To Abiotic Stimulus Thalamus Development Histone H2A Ubiquitination Response To UV-B Cyclooxygenase Pathway Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Histone Monoubiquitination Positive Regulation Of Viral Genome Replication Regulation Of Activin Receptor Signaling Pathway Prostaglandin Biosynthetic Process Regulation Of Viral Release From Host Cell MRNA Processing Hypothalamus Development
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