LYPD3 and PPM1D

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		LYPD3	PPM1D
Description		LY6/PLAUR domain containing 3	protein phosphatase, Mg2+/Mn2+ dependent 1D
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Side Of Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Laminin Binding	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Cotinine glucuronidation ( 25293881)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		17 interacting genes: AGR2 AGR3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11	25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		27076	8493
HPRD ID		10783	05482
Ensembl ID		ENSG00000124466	ENSG00000170836
Uniprot IDs		B2RBR3 O95274	A0A0S2Z4M2 O15297
PDB IDs		6IOM 6ION	8T2J
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cell Projection Organization Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Glycoside Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Anoikis Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Cycle G2/M Phase Transition Phosphorylation Negative Regulation Of Signal Transduction Dystroglycan Binding Carbohydrate Homeostasis Glucose Homeostasis Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Autophagosome Assembly Protein Kinase Activity Heart Development Positive Regulation Of Metabolic Process Autophagosome Organization Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mitogen-activated Protein Kinase Binding Regulation Of Signal Transduction By P53 Class Mediator Phosphate-containing Compound Metabolic Process Regulation Of Growth	Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding
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