LYPD3 and LSP1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		LYPD3	LSP1
Description		LY6/PLAUR domain containing 3	lymphocyte specific protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Side Of Membrane	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	Laminin Binding	Actin Binding Protein Binding
	Biological Process	Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways		Post-translational modification: synthesis of GPI-anchored proteins
Drugs
Diseases
GWAS		Cotinine glucuronidation ( 25293881)	Bladder cancer ( 24163127) Breast cancer ( 20453838 17529967 23535729 29059683 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30487518 27618452 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Potassium levels ( 29403010) Pulse pressure ( 30578418 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		17 interacting genes: AGR2 AGR3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		27076	4046
HPRD ID		10783	01083
Ensembl ID		ENSG00000124466	ENSG00000130592
Uniprot IDs		B2RBR3 O95274	A8K7L8 P33241
PDB IDs		6IOM 6ION	3BH8 4NO0 4NO2
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cell Projection Organization Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Glycoside Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Anoikis Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Cycle G2/M Phase Transition Phosphorylation Negative Regulation Of Signal Transduction Dystroglycan Binding Carbohydrate Homeostasis Glucose Homeostasis Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Autophagosome Assembly Protein Kinase Activity Heart Development Positive Regulation Of Metabolic Process Autophagosome Organization Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mitogen-activated Protein Kinase Binding Regulation Of Signal Transduction By P53 Class Mediator Phosphate-containing Compound Metabolic Process Regulation Of Growth
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