PPM1D

Description		protein phosphatase, Mg2+/Mn2+ dependent 1D
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)
Novel Interacting Genes		1 novel interacting genes: ATP6V1A
Interacting Genes		25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC
Entrez ID		8493
HPRD ID		05482
Ensembl ID		ENSG00000170836
Uniprot IDs		A0A0S2Z4M2 O15297
PDB IDs		8T2J
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding
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