LYPD3 and CTRB1

Number of citations of the paper that reports this interaction (PubMedID 15012588)
37

Data Source:
HPRD (in vitro)

		LYPD3	CTRB1
Description		LY6/PLAUR domain containing 3	chymotrypsinogen B1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Side Of Membrane	Extracellular Region
	Molecular Function	Laminin Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Cell-matrix Adhesion Negative Regulation Of Smooth Muscle Cell Apoptotic Process	Proteolysis Digestion
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Activation of Matrix Metalloproteinases Uptake of dietary cobalamins into enterocytes
Drugs			Trans-O-Hydroxy-Alpha-Methyl Cinnamate 2,4-Dihydroxy-Trans Cinnamic Acid Phenylethane Boronic Acid Phosphorylisopropane Aprotinin 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) N-(1-BENZYL-3,3,3-TRIFLUORO-2,2-DIHYDROXY-PROPYL)-ACETAMIDE alpha-Methyl-2-hydroxy-4-diethylaminocinnamic acid 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE (2S) N-acetyl-L-alanyl-αL-phenylalanyl-chloroethylketone 1,1,1-TRIFLUORO-3-((N-ACETYL)-L-LEUCYLAMIDO)-4-PHENYL-BUTAN-2-ONE(N-ACETYL-L-LEUCYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE) Phenylalanylmethylchloride L-1-naphthyl-2-acetamido-ethane boronic acid D-1-naphthyl-2-acetamido-ethane boronic acid D-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid L-1-(4-chlorophenyl)-2-(acetamido)ethane boronic acid
Diseases
GWAS		Cotinine glucuronidation ( 25293881)	Advanced age-related macular degeneration ( 26691988) Alcoholic chronic pancreatitis ( 28754779) Chronic obstructive pulmonary disease or coronary artery disease (pleiotropy) ( 30940143) Pancreatic cancer ( 25086665) Type 2 diabetes ( 30054458)
Interacting Genes		17 interacting genes: AGR2 AGR3 AURKA BAG4 BRMS1 CASP8 CHEK2 CTRB1 ERBB2 IGF1R LSP1 PALB2 PPM1D PTPRJ RB1CC1 SMAD4 STK11	4 interacting genes: LYPD3 SERPINA1 SERPINA3 SERPINF2
Entrez ID		27076	1504
HPRD ID		10783	00345
Ensembl ID		ENSG00000124466	ENSG00000168925
Uniprot IDs		B2RBR3 O95274	P17538
PDB IDs		6IOM 6ION
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Signal Transduction Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Cell Projection Organization Protein Autophosphorylation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Response To Glycoside Plasma Membrane Bounded Cell Projection Organization Apoptotic Process Negative Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Protein Phosphorylation G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Anoikis Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Cycle G2/M Phase Transition Phosphorylation Negative Regulation Of Signal Transduction Dystroglycan Binding Carbohydrate Homeostasis Glucose Homeostasis Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Cell Population Proliferation Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Protein Dephosphorylation Autophagosome Assembly Protein Kinase Activity Heart Development Positive Regulation Of Metabolic Process Autophagosome Organization Signal Transduction By P53 Class Mediator Negative Regulation Of Apoptotic Process Extrinsic Apoptotic Signaling Pathway Ubiquitin Protein Ligase Binding Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Mitogen-activated Protein Kinase Binding Regulation Of Signal Transduction By P53 Class Mediator Phosphate-containing Compound Metabolic Process Regulation Of Growth	Acute-phase Response Platelet Alpha Granule Lumen Acute Inflammatory Response Serine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Extracellular Space Inflammatory Response Extracellular Region Protease Binding Blood Microparticle Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Regulation Of Body Fluid Levels Negative Regulation Of Plasminogen Activation Defense Response Fibrinogen Complex Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Fibrinolysis Maintenance Of Gastrointestinal Epithelium Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Transforming Growth Factor Beta Production Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Positive Regulation Of Collagen Biosynthetic Process Laminin Binding Negative Regulation Of Smooth Muscle Cell Apoptotic Process Extracellular Exosome Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Positive Regulation Of Coagulation Epithelial Structure Maintenance COPII-coated ER To Golgi Transport Vesicle Regulation Of Smooth Muscle Cell Apoptotic Process Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Systemic Arterial Blood Pressure Endopeptidase Inhibitor Activity
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