PPM1D and MRC2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PPM1D	MRC2
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	mannose receptor C-type 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Focal Adhesion Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding	Protein Binding Collagen Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction	Osteoblast Differentiation Endocytosis Collagen Catabolic Process
Pathways		Transcriptional regulation by RUNX2	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes)
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Diastolic blood pressure ( 28135244 30578418) Heel bone mineral density ( 30598549) Pulse pressure ( 28135244 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	14 interacting genes: AKT1 BAG4 BRMS1 ESR2 MTDH NDEL1 PALB2 PAX2 PPM1D PTPN1 RAF1 RB1CC1 SLC26A4-AS1 XRCC3
Entrez ID		8493	9902
HPRD ID		05482	10094
Ensembl ID		ENSG00000170836	ENSG00000011028
Uniprot IDs		A0A0S2Z4M2 O15297	Q9UBG0
PDB IDs		8T2J	5AO5 5AO6 5E4K 5E4L 5EW6
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding	Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Insulin Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Vascular Endothelial Cell Response To Fluid Shear Stress Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Intracellular Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Fibroblast Migration Inner Cell Mass Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Stem Cell Population Maintenance Enzyme Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Apoptotic Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Regulation Of Extrinsic Apoptotic Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Cellular Response To Fluid Shear Stress Negative Regulation Of Macromolecule Metabolic Process NF-kappaB Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Lipopolysaccharide-mediated Signaling Pathway Carbohydrate Homeostasis Apoptotic Process Negative Regulation Of Metabolic Process Glucose Homeostasis Regulation Of Fibroblast Migration Negative Regulation Of RNA Metabolic Process Response To Fluid Shear Stress Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Programmed Cell Death Cell Death Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Response To Epidermal Growth Factor
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