PPM1D and OSGIN1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		PPM1D	OSGIN1
Description		protein phosphatase, Mg2+/Mn2+ dependent 1D	oxidative stress induced growth inhibitor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Midbody
	Molecular Function	Protein Serine/threonine Kinase Activity Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding Mitogen-activated Protein Kinase Binding	Monooxygenase Activity Protein Binding Growth Factor Activity Oxidoreductase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle DNA Methylation-dependent Constitutive Heterochromatin Formation Protein Dephosphorylation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Radiation Response To Bacterium DNA Damage Response, Signal Transduction By P53 Class Mediator Peptidyl-threonine Dephosphorylation Negative Regulation Of Gene Expression, Epigenetic Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Intracellular Signal Transduction	Signal Transduction Cell Differentiation Negative Regulation Of Cell Growth
Pathways		Transcriptional regulation by RUNX2
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163)	Alanine aminotransferase levels ( 33547301) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Pursuit maintenance gain ( 29064472) Response to platinum-based neoadjuvant chemotherapy in cervical cancer ( 28120872) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		25 interacting genes: BEX2 CASZ1 CDKN1A CHEK2 DIRAS3 DKK3 EPSTI1 ERRFI1 GLCE H3-3A H3C1 ITIH5 KDM1A LYPD3 MAPK11 MDM2 MRC2 NAT2 NCL NSD3 OSGIN1 RHOBTB2 RPL5 TP53 UBC	47 interacting genes: AKT1 ARNT2 ATM BCAR3 BEND7 BTBD2 CAPN3 CCDC33 CENPN CRX DECR2 DNAJA3 FGFR4 GCLM HOMEZ IKBKG IKZF3 INCA1 KATNBL1 KRAS KRT75 LNX1 MEI4 MEIS2 MEOX1 MEOX2 MTERF4 PAX5 PDE4A PDE4C PICK1 POLDIP3 POLR2G PPM1D PTEN REL SAXO1 SMARCB1 SORBS3 TCF12 TCF4 TLE5 TRIM54 XRCC3 ZBTB42 ZC2HC1C ZKSCAN4
Entrez ID		8493	29948
HPRD ID		05482	06412
Ensembl ID		ENSG00000170836	ENSG00000140961
Uniprot IDs		A0A0S2Z4M2 O15297	Q9UJX0
PDB IDs		8T2J
Enriched GO Terms of Interacting Partners?		Cellular Response To Gamma Radiation Response To Gamma Radiation Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Radiation Cellular Response To Light Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Replicative Senescence Response To Ionizing Radiation Response To UV Ubiquitin Protein Ligase Binding Cellular Response To Actinomycin D Response To Actinomycin D Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Cellular Response To UV-C Response To Antibiotic Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Regulation Of Protein Metabolic Process Stress-induced Premature Senescence Epigenetic Regulation Of Gene Expression Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Catalytic Activity Cellular Response To Antibiotic 5S RRNA Binding Protein-containing Complex Response To Light Stimulus Cellular Senescence Thymocyte Apoptotic Process Mitotic DNA Damage Checkpoint Signaling P53 Binding Mitotic DNA Integrity Checkpoint Signaling Cellular Response To UV-B Response To UV-C Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic G1 DNA Damage Checkpoint Signaling Mitotic G1/S Transition Checkpoint Signaling Regulation Of Protein Modification Process Negative Regulation Of Growth Chromatin Remodeling DNA Damage Checkpoint Signaling Response To UV-B Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator MRNA 5'-UTR Binding	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Protein-containing Complex Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Protein Binding DNA Binding Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Somite Specification Positive Regulation Of Metabolic Process Chromatin Regulation Of Metabolic Process Nervous System Development Activation-induced Cell Death Of T Cells Identical Protein Binding Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Developmental Process Response To Nitrosative Stress Positive Regulation Of Proteolysis CAMP Catabolic Process Regulation Of Cell Communication Regulation Of Signaling System Development Regulation Of Cell Population Proliferation Anoikis HMG Box Domain Binding Nucleus Embryonic Pattern Specification Cyclic Nucleotide Catabolic Process Myelin Maintenance Nucleoplasm Positive Regulation Of Intracellular Signal Transduction Segment Specification
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