GJA5 and AAR2

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GJA5	AAR2
Gene Name		gap junction protein, alpha 5, 40kDa	AAR2 splicing factor homolog (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Gap Junction Connexon Complex Intercalated Disc Cell Projection
	Molecular Function	Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling
	Biological Process	Skeletal System Development Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication By Chemical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Artery Morphogenesis Protein Oligomerization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)
Protein-Protein Interactions		5 interactors: AAR2 GJA1 MARK1 PRKACA RIMS3	2 interactors: EAPP GJA5
Entrez ID		2702	25980
HPRD ID		08699	12767
Ensembl ID		ENSG00000143140	ENSG00000131043
Uniprot IDs		P36382	Q9Y312
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Tight Junction Assembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cardiac Conduction Regulation Of Cell Junction Assembly Regulation Of Cardiac Muscle Contraction Regulation Of Endothelial Cell Proliferation Regulation Of Secretion Regulation Of Striated Muscle Contraction Renal System Process Cell-cell Junction Assembly Positive Regulation Of Dense Core Granule Biogenesis Milk Ejection Vascular Transport Positive Regulation Of Behavior Cell Migration Regulation Of Osteoblast Differentiation Regulation Of Wound Healing Response To Glucose Cell Motility Cell Maturation Regulation Of Muscle Contraction Regulation Of Ion Homeostasis Regulation Of Heart Contraction Neuron Migration Positive Regulation Of Cell Communication By Chemical Coupling Histone H3-T6 Phosphorylation Atrial Ventricular Junction Remodeling Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Response To Carbohydrate Regulation Of Behavior Regulation Of Calcium Ion Transport Regulation Of Ossification Regulation Of Insulin Secretion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Peptide Hormone Secretion Locomotion Cell Communication By Chemical Coupling Regulation Of Hormone Secretion Regulation Of Membrane Potential Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis ATP Transport Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Regulation Of Synaptic Transmission Peptidyl-serine Autophosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization	Vasomotion AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Atrial Ventricular Junction Remodeling Pulmonary Valve Formation Positive Regulation Of Cell Communication By Chemical Coupling Foramen Ovale Closure Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Chemical Coupling Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Negative Regulation Of Glomerular Filtration Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Mitral Valve Development SA Node Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Regulation Of Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Pulmonary Valve Morphogenesis Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization SA Node Cell To Atrial Cardiac Muscle Cell Communication Atrial Cardiac Muscle Cell To AV Node Cell Communication Atrial Cardiac Muscle Cell Action Potential Septum Primum Development Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Glomerular Filtration Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Cardiac Conduction System Development Cell Communication By Electrical Coupling Cell-cell Signaling Involved In Cardiac Conduction Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Heart Valve Formation Atrial Septum Morphogenesis Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Ventricular Cardiac Muscle Cell Action Potential Atrial Septum Development Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Atrioventricular Valve Development Gap Junction Assembly Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of DNA-templated Transcription, Elongation Ventricular Septum Morphogenesis Cardiac Atrium Morphogenesis Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Heart Valve Morphogenesis Regulation Of Membrane Depolarization Regulation Of Transcription Elongation From RNA Polymerase II Promoter Heart Valve Development
Tagcloud ?		aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs gap gja1 inducer junction junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin	arm basic chromoblot chromosome clone closely consensus copy cosmid deduced frames hsp70 insert kb leader orf orfs precisely reading ribosomal rpg s40 s8 segment sequenced splice ssa3 ssa4 viii
Tagcloud (Difference) ?		aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs gap gja1 inducer junction junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin	arm basic chromoblot chromosome clone closely consensus copy cosmid deduced frames hsp70 insert kb leader orf orfs precisely reading ribosomal rpg s40 s8 segment sequenced splice ssa3 ssa4 viii
Tagcloud (Intersection) ?