GJA5 and MARK1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		GJA5	MARK1
Gene Name		gap junction protein, alpha 5, 40kDa	MAP/microtubule affinity-regulating kinase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Gap Junction Connexon Complex Intercalated Disc Cell Projection	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton
	Molecular Function	Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling	Magnesium Ion Binding Phosphatidylserine Binding Protein Serine/threonine Kinase Activity ATP Binding Phosphatidylinositol-4,5-bisphosphate Binding Tau-protein Kinase Activity Phosphatidic Acid Binding
	Biological Process	Skeletal System Development Angiogenesis Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication By Chemical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Vasodilation Artery Morphogenesis Protein Oligomerization Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Bundle Of His Cell To Purkinje Myocyte Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion	Neuron Migration Protein Phosphorylation Cytoskeleton Organization Wnt Signaling Pathway Intracellular Signal Transduction
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking
Drugs
Diseases
GWAS		Cognitive performance ( 20125193)	Bipolar disorder ( 22205951) Fat distribution (HIV) ( 21897333)
Protein-Protein Interactions		5 interactors: AAR2 GJA1 MARK1 PRKACA RIMS3	7 interactors: CCDC102B GJA5 MAP2 MAP4 MAPT STK11 TAOK1
Entrez ID		2702	4139
HPRD ID		08699	07353
Ensembl ID		ENSG00000143140	ENSG00000116141
Uniprot IDs		P36382	B4DIB3 Q9P0L2
PDB IDs			2HAK 3OSE
Enriched GO Terms of Interacting Partners?		Regulation Of Tight Junction Assembly Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication By Electrical Coupling Cardiac Conduction Regulation Of Cell Junction Assembly Regulation Of Cardiac Muscle Contraction Regulation Of Endothelial Cell Proliferation Regulation Of Secretion Regulation Of Striated Muscle Contraction Renal System Process Cell-cell Junction Assembly Positive Regulation Of Dense Core Granule Biogenesis Milk Ejection Vascular Transport Positive Regulation Of Behavior Cell Migration Regulation Of Osteoblast Differentiation Regulation Of Wound Healing Response To Glucose Cell Motility Cell Maturation Regulation Of Muscle Contraction Regulation Of Ion Homeostasis Regulation Of Heart Contraction Neuron Migration Positive Regulation Of Cell Communication By Chemical Coupling Histone H3-T6 Phosphorylation Atrial Ventricular Junction Remodeling Regulation Of Cellular Localization Cytosolic Calcium Ion Homeostasis Response To Carbohydrate Regulation Of Behavior Regulation Of Calcium Ion Transport Regulation Of Ossification Regulation Of Insulin Secretion Cell Junction Assembly Cell-cell Junction Organization Regulation Of Peptide Hormone Secretion Locomotion Cell Communication By Chemical Coupling Regulation Of Hormone Secretion Regulation Of Membrane Potential Regulation Of Epithelial Cell Proliferation Cellular Calcium Ion Homeostasis ATP Transport Movement Of Cell Or Subcellular Component Calcium Ion Homeostasis Regulation Of Synaptic Transmission Peptidyl-serine Autophosphorylation Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization	Organelle Localization Microtubule Cytoskeleton Organization Execution Phase Of Apoptosis Positive Regulation Of Axonogenesis Axonogenesis Vasomotion Microtubule Sliding AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling TCR Signalosome Assembly Axon Development Cell Morphogenesis Involved In Neuron Differentiation Establishment Of Cell Polarity Neuron Projection Morphogenesis Atrial Ventricular Junction Remodeling Pulmonary Valve Formation Foramen Ovale Closure Positive Regulation Of Cell Communication By Chemical Coupling Cell Morphogenesis Involved In Differentiation Microtubule-based Process Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Establishment Or Maintenance Of Cell Polarity Cell Part Morphogenesis Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Cell Communication By Chemical Coupling Regulation Of Membrane Depolarization During Action Potential AV Node Cell To Bundle Of His Cell Communication Neuron Development Apoptotic Process Positive Regulation Of Neuron Projection Development Anatomical Structure Morphogenesis Programmed Cell Death Negative Regulation Of Glomerular Filtration Cell Cycle Process Cell Death Death Cell Morphogenesis Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Mitral Valve Development SA Node Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Anoikis Cellular Response To UV-B Regulation Of Cardiac Muscle Cell Action Potential Bundle Of His Cell To Purkinje Myocyte Communication Neuron Differentiation Cytoskeleton Organization Activation Of Protein Kinase Activity
Tagcloud ?		aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs gap gja1 inducer junction junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin	backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning
Tagcloud (Difference) ?		aggregates automaticity beating cardiomyocyte cav1 cav3 contraction dimethyl dmso embryonal fbs gap gja1 inducer junction junctions medicinal mem methyltryptanthrin myocardium nonbeating p19cl6 pacemaker polygonum spontaneously sulfoxide synchronized tinctorium tryptanthrin	backgroundprocess behavior broadly conclusionsthe coping eating engagement improvements informed intervention inverted mark0 mark2 mark5 mediators methods108 motivation motivational pmblc pmlbc question r2 resultsthe specified theoretical theoretically theories underpinning
Tagcloud (Intersection) ?