GJA5 and SLC41A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJA5	SLC41A1
Description		gap junction protein alpha 5	solute carrier family 41 member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Membrane Cell Projection Anchoring Junction	Plasma Membrane Membrane Basolateral Plasma Membrane Protein-containing Complex
	Molecular Function	Gap Junction Channel Activity Protein Binding Gap Junction Hemi-channel Activity Connexin Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Disordered Domain Specific Binding	Protein Binding Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transmembrane Transporter Activity Transmembrane Transporter Activity Inorganic Cation Transmembrane Transporter Activity Magnesium:sodium Antiporter Activity
	Biological Process	Skeletal System Development Angiogenesis Blood Vessel Development Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Glomerular Filtration Outflow Tract Morphogenesis Endothelium Development Cardiac Conduction System Development Mitral Valve Development Pulmonary Valve Formation Ventricular Septum Development Atrial Septum Development Septum Primum Development Atrial Ventricular Junction Remodeling Potassium Ion Transport Cell Communication Cell-cell Signaling Heart Development Cell Communication By Chemical Coupling Cell Communication By Electrical Coupling Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication By Chemical Coupling Gap Junction Assembly Embryonic Limb Morphogenesis Embryonic Heart Tube Development Foramen Ovale Closure Vasodilation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Artery Morphogenesis Transmembrane Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Cardiac Conduction Ventricular Cardiac Muscle Cell Action Potential SA Node Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling Bundle Of His Cell To Purkinje Myocyte Communication By Electrical Coupling Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cell Communication Involved In Cardiac Conduction AV Node Cell To Bundle Of His Cell Communication Regulation Of Heart Rate By Cardiac Conduction Blood Vessel Diameter Maintenance Regulation Of AV Node Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Purkinje Myocyte Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Renin Secretion Into Blood Stream Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Vasomotion	Monoatomic Ion Transport Monoatomic Cation Transport Intracellular Magnesium Ion Homeostasis Magnesium Ion Transport Metal Ion Transport Sodium Ion Transmembrane Transport Cellular Response To Magnesium Ion Magnesium Ion Transmembrane Transport
Pathways		Gap junction assembly	Metal ion SLC transporters
Drugs
Diseases		Atrial fibrillation
GWAS		Atrial fibrillation ( 29892015 30061737) Cognitive performance ( 20125193) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057) PR interval ( 32439900) Triglyceride levels ( 34074324)	Allergic sensitization ( 30013184) Atrial fibrillation ( 30061737) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Monocyte count ( 27863252 32888494) Parkinson's disease ( 28892059 21738487 19915576) Plateletcrit ( 32888494) Prostate cancer ( 25217961) Prostate-specific antigen levels ( 25434496 23269536) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		34 interacting genes: AAR2 ABHD16A ARLN BLCAP EMP3 FCER1G GJA1 GJB2 IGFBP5 LEPROT LEPROTL1 LHFPL2 MARK1 MS4A13 NIPAL3 NKG7 PGAP2 PRAF2 PRKACA RIMS3 RPRM SLC13A4 SLC30A2 SLC35F1 SLC41A1 SLC41A2 SLC61A1 SLC66A1 TMBIM6 TMEM107 TREX1 UBQLN4 VRK2 YIPF6	32 interacting genes: AMIGO1 AQP6 AVPR2 CD79A CLN5 ELOVL7 ERGIC3 FAM209A FFAR2 FFAR3 GJA5 GJB5 GPR101 GPR152 GPR42 KASH5 LHFPL5 OPRM1 SLC10A1 SLC10A6 SLC13A4 SLC23A2 SSMEM1 SYNDIG1 SYPL2 TAAR9 TBXA2R TLCD4 TMEM237 TMEM248 TMEM31 TRHR
Entrez ID		2702	254428
HPRD ID		08699	15388
Ensembl ID		ENSG00000265107	ENSG00000133065
Uniprot IDs		P36382 X5D2H9	B2RMP2 Q8IVJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Monoatomic Cation Transmembrane Transporter Activity Magnesium Ion Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transmembrane Transport Transmembrane Transport Cell Communication By Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Inorganic Cation Transmembrane Transporter Activity Gap Junction Assembly Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Protein Binding Monoatomic Ion Transport Transmembrane Transporter Activity Cell Communication By Electrical Coupling Involved In Cardiac Conduction Monoatomic Ion Transmembrane Transport Connexin Complex Gap Junction Channel Activity	Membrane G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Positive Regulation Of Vasoconstriction Bile Acid:sodium Symporter Activity Symporter Activity Renal Water Transport Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Vasoconstriction Regulation Of Blood Pressure Sodium Ion Transport Protein Binding Connexin Complex Nitrate Transmembrane Transporter Activity Transmembrane Transport Water Transport Renal System Process System Process Renal Water Retention Positive Regulation Of Blood Pressure Bis(monoacylglycero)phosphate Synthase Activity Positive Regulation Of GTP Binding Vacuolar Lumen Gap Junction Channel Activity Involved In Purkinje Myocyte-ventricular Cardiac Muscle Cell Electrical Coupling Mitral Valve Development Septum Primum Development Gap Junction Channel Activity Involved In Atrial Cardiac Muscle Cell-AV Node Cell Electrical Coupling Gap Junction Atrial Ventricular Junction Remodeling Gap Junction Channel Activity Involved In Bundle Of His Cell-Purkinje Myocyte Electrical Coupling Gap Junction Channel Activity Positive Regulation Of Cell Communication By Chemical Coupling Atrial Cardiac Muscle Cell To AV Node Cell Communication By Electrical Coupling Metal Ion Transport Vasomotion Purkinje Myocyte To Ventricular Cardiac Muscle Cell Communication By Electrical Coupling Regulation Of Purkinje Myocyte Action Potential Positive Regulation Of Acute Inflammatory Response Mucosal Immune Response Organ Or Tissue Specific Immune Response Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Response To Ethanol Bile Acid And Bile Salt Transport
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