GJA3 and TJP1

Number of citations of the paper that reports this interaction (PMID 12808044)
34

Data Source:
HPRD (in vivo, in vitro)

		GJA3	TJP1
Gene Name		gap junction protein, alpha 3, 46kDa	tight junction protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Connexon Complex Integral Component Of Membrane	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Gap Junction Channel Activity	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Transport Cell-cell Signaling Visual Perception Transmembrane Transport	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking	Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		5 interactors: CAV1 GJA1 MIP PRKCG TJP1	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		2700	7082
HPRD ID		00415	03002
Ensembl ID		ENSG00000121743	ENSG00000104067
Uniprot IDs		Q9Y6H8	G3V1L9 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Cellular Chemical Homeostasis Cellular Homeostasis Regulation Of Membrane Repolarization Chemical Homeostasis Positive Regulation Of Vasoconstriction Negative Regulation Of Endothelial Cell Proliferation Blood Circulation Regulation Of Cardiac Muscle Cell Contraction Homeostatic Process Regulation Of Vasoconstriction Regulation Of Cardiac Muscle Contraction Regulation Of Endothelial Cell Proliferation Regulation Of Striated Muscle Contraction Regulation Of Body Fluid Levels Endothelium Development Wound Healing Lens Development In Camera-type Eye Negative Regulation Of Protein Ubiquitination Cell-cell Signaling Involved In Cell-cell Junction Organization Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Mismatch Repair Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Milk Ejection Vascular Transport Tissue Remodeling Response To Wounding Cell-cell Junction Assembly Negative Regulation Of Epithelial Cell Proliferation Regulation Of Wound Healing Response To Glucose Multicellular Organismal Development Anatomical Structure Development Regulation Of Mismatch Repair Positive Regulation Of Cell Communication By Chemical Coupling Nitric Oxide Homeostasis Atrial Ventricular Junction Remodeling Regulation Of Muscle Contraction Membrane Organization Regulation Of Ion Homeostasis Regulation Of Heart Contraction Cell-cell Signaling Cytosolic Calcium Ion Homeostasis Response To Organic Substance Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Inward Rectifier Potassium Channel Activity Response To Carbohydrate Regulation Of Calcium Ion Transport Apoptotic Process Developmental Process	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?		aiims beaded bfsp1 cataract congenital cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja8 m1v ophthalmic sciences studio transparency y67n	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?		aiims beaded bfsp1 cataract congenital cryaa cryab cryba1 cryba4 crybb1 crybb2 crybb3 crygs crystallin cx d85n delhi e155k e75k expands filament fourteen gja8 m1v ophthalmic sciences studio transparency y67n	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?