GJA3 and TJP1

Number of citations of the paper that reports this interaction (PubMedID 12808044)
51

Data Source:
HPRD (in vivo, in vitro)

		GJA3	TJP1
Description		gap junction protein alpha 3	tight junction protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Podosome Cytoplasm Cytosol Plasma Membrane Adherens Junction Gap Junction Bicellular Tight Junction Membrane Basolateral Plasma Membrane Cell Junction Protein-containing Complex Cell Projection Apical Junction Complex Apical Part Of Cell Tight Junction Anchoring Junction
	Molecular Function	Gap Junction Channel Activity Gap Junction Hemi-channel Activity	Protein Binding Calmodulin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	Cell Communication Cell-cell Signaling Visual Perception Transmembrane Transport Gap Junction-mediated Intercellular Transport	Cell-cell Junction Assembly Positive Regulation Of Cell Population Proliferation Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Actomyosin Structure Organization Adherens Junction Maintenance Maintenance Of Blood-brain Barrier Ameloblast Differentiation Negative Regulation Of Apoptotic Process Cell-cell Junction Organization Regulation Of Cytoskeleton Organization Negative Regulation Of Stress Fiber Assembly Protein Localization To Adherens Junction Establishment Of Endothelial Intestinal Barrier Cell-cell Adhesion Protein Localization To Cell-cell Junction Regulation Of Cell Junction Assembly Protein Localization To Bicellular Tight Junction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Blood-brain Barrier Permeability Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Regulation Of Bicellular Tight Junction Assembly
Pathways		Gap junction assembly	Regulation of gap junction activity Regulation of gap junction activity Signaling by Hippo Apoptotic cleavage of cell adhesion proteins RUNX1 regulates expression of components of tight junctions SARS-CoV-2 targets PDZ proteins in cell-cell junction SARS-CoV-2 targets PDZ proteins in cell-cell junction
Drugs
Diseases
GWAS		Body fat mass ( 28552196) Facial emotion recognition (happy faces) ( 28608620) Pericalcarine cortex volume ( 31530798)	Central corneal thickness ( 29760442 30894546 31798171 32528159) Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943) Spleen volume ( 34128465)
Interacting Genes		5 interacting genes: CAV1 GJA1 MIP PRKCG TJP1	40 interacting genes: ACTA1 ACTN4 AFDN ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL1 PEA15 PTPN14 TJP2 TJP3 TRPC4 TTC3 UBN1 YBX3
Entrez ID		2700	7082
HPRD ID		00415	03002
Ensembl ID		ENSG00000121743	ENSG00000104067
Uniprot IDs		Q9Y6H8	A0A087X0K9 A0A0G2JNH2 A0A7I2V5U5 A9CQZ8 B4DZK4 G3V1L9 G5E9E7 Q07157
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ 4OEO 4OEP 4Q2Q 4YYX
Enriched GO Terms of Interacting Partners?		Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Maintenance Of Blood-brain Barrier Tight Junction Apical Plasma Membrane Anchoring Junction Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Protein Ubiquitination Homeostatic Process Tissue Remodeling System Process Negative Regulation Of Post-translational Protein Modification Multicellular Organismal-level Homeostasis Positive Regulation Of Cold-induced Thermogenesis Cell-cell Junction Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Apoptotic Process Plasma Membrane Insulin Receptor Internalization Regulation Of Protein Ubiquitination Protein Localization To Basolateral Plasma Membrane Protein Localization To Plasma Membrane Raft Regulation Of Cold-induced Thermogenesis Intracellular Nitric Oxide Homeostasis Nitric-oxide Synthase Inhibitor Activity Caveolin-mediated Endocytosis Striated Muscle Tissue Development Caveolar Macromolecular Signaling Complex Muscle Tissue Development Negative Regulation Of Pinocytosis Mammary Gland Involution Negative Regulation Of Programmed Cell Death Cellular Response To Hyperoxia Cell-cell Junction Organization Gap Junction Hemi-channel Activity Positive Regulation Of Mesodermal Cell Differentiation Cell Junction Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Calmodulin Binding Response To Psychosocial Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair Regulation Of Mismatch Repair Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Membrane Raft Regulation Of Cellular Component Organization Regulation Of Cell Junction Assembly	Anchoring Junction Bicellular Tight Junction Cell-cell Junction Organization Tight Junction Cell-cell Junction Assembly Cell Junction Organization Cell Junction Assembly Cell-cell Adhesion Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Bicellular Tight Junction Assembly Cell Junction Tight Junction Assembly Maintenance Of Blood-brain Barrier Tight Junction Organization Cell Adhesion Plasma Membrane Apicolateral Plasma Membrane Connexin Complex Gap Junction Channel Activity Structural Molecule Activity Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Establishment Of Endothelial Intestinal Barrier Establishment Of Endothelial Barrier Endothelial Cell Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Gap Junction Assembly Cadherin Binding Cell-cell Contact Zone Lateral Plasma Membrane Cell Development Cellular Component Assembly Multicellular Organismal-level Homeostasis Paracellular Transport System Process Epithelial Cell Development Cell-cell Signaling Identical Protein Binding Intercellular Transport Basolateral Plasma Membrane Signaling Cell Communication Membrane Intercalated Disc Regulation Of Locomotion Homeostatic Process Cell Communication By Electrical Coupling Involved In Cardiac Conduction Developmental Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?