GJA3 and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 15467523)
0

Data Source:
HPRD (in vivo)

		GJA3	PRKCG
Description		gap junction protein alpha 3	protein kinase C gamma
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Gap Junction Channel Activity Gap Junction Hemi-channel Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Communication Cell-cell Signaling Visual Perception Transmembrane Transport Gap Junction-mediated Intercellular Transport	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		Gap junction assembly	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs			Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Body fat mass ( 28552196) Facial emotion recognition (happy faces) ( 28608620) Pericalcarine cortex volume ( 31530798)
Interacting Genes		5 interacting genes: CAV1 GJA1 MIP PRKCG TJP1	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		2700	5582
HPRD ID		00415	01502
Ensembl ID		ENSG00000121743	ENSG00000126583
Uniprot IDs		Q9Y6H8	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs			2E73 2UZP
Enriched GO Terms of Interacting Partners?		Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Maintenance Of Blood-brain Barrier Tight Junction Apical Plasma Membrane Anchoring Junction Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Protein Ubiquitination Homeostatic Process Tissue Remodeling System Process Negative Regulation Of Post-translational Protein Modification Multicellular Organismal-level Homeostasis Positive Regulation Of Cold-induced Thermogenesis Cell-cell Junction Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Apoptotic Process Plasma Membrane Insulin Receptor Internalization Regulation Of Protein Ubiquitination Protein Localization To Basolateral Plasma Membrane Protein Localization To Plasma Membrane Raft Regulation Of Cold-induced Thermogenesis Intracellular Nitric Oxide Homeostasis Nitric-oxide Synthase Inhibitor Activity Caveolin-mediated Endocytosis Striated Muscle Tissue Development Caveolar Macromolecular Signaling Complex Muscle Tissue Development Negative Regulation Of Pinocytosis Mammary Gland Involution Negative Regulation Of Programmed Cell Death Cellular Response To Hyperoxia Cell-cell Junction Organization Gap Junction Hemi-channel Activity Positive Regulation Of Mesodermal Cell Differentiation Cell Junction Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Calmodulin Binding Response To Psychosocial Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair Regulation Of Mismatch Repair Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Membrane Raft Regulation Of Cellular Component Organization Regulation Of Cell Junction Assembly	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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