GJA3 and MIP

Number of citations of the paper that reports this interaction (PubMedID 9664032)
0

Data Source:
HPRD (in vivo)

		GJA3	MIP
Description		gap junction protein alpha 3	major intrinsic protein of lens fiber
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	Gap Junction Channel Activity Gap Junction Hemi-channel Activity	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity
	Biological Process	Cell Communication Cell-cell Signaling Visual Perception Transmembrane Transport Gap Junction-mediated Intercellular Transport	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways		Gap junction assembly	Passive transport by Aquaporins
Drugs			B-nonylglucoside
Diseases
GWAS		Body fat mass ( 28552196) Facial emotion recognition (happy faces) ( 28608620) Pericalcarine cortex volume ( 31530798)	Axial length ( 24144296) Lipoprotein (a) levels ( 33730874) Serum metabolite levels ( 33031748)
Interacting Genes		5 interacting genes: CAV1 GJA1 MIP PRKCG TJP1	48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		2700	4284
HPRD ID		00415	01098
Ensembl ID		ENSG00000121743	ENSG00000135517
Uniprot IDs		Q9Y6H8	P30301
PDB IDs
Enriched GO Terms of Interacting Partners?		Anatomical Structure Homeostasis Tissue Homeostasis Gap Junction Maintenance Of Blood-brain Barrier Tight Junction Apical Plasma Membrane Anchoring Junction Inward Rectifier Potassium Channel Inhibitor Activity Negative Regulation Of Protein Ubiquitination Homeostatic Process Tissue Remodeling System Process Negative Regulation Of Post-translational Protein Modification Multicellular Organismal-level Homeostasis Positive Regulation Of Cold-induced Thermogenesis Cell-cell Junction Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Apoptotic Process Plasma Membrane Insulin Receptor Internalization Regulation Of Protein Ubiquitination Protein Localization To Basolateral Plasma Membrane Protein Localization To Plasma Membrane Raft Regulation Of Cold-induced Thermogenesis Intracellular Nitric Oxide Homeostasis Nitric-oxide Synthase Inhibitor Activity Caveolin-mediated Endocytosis Striated Muscle Tissue Development Caveolar Macromolecular Signaling Complex Muscle Tissue Development Negative Regulation Of Pinocytosis Mammary Gland Involution Negative Regulation Of Programmed Cell Death Cellular Response To Hyperoxia Cell-cell Junction Organization Gap Junction Hemi-channel Activity Positive Regulation Of Mesodermal Cell Differentiation Cell Junction Gap Junction Channel Activity Involved In Cardiac Conduction Electrical Coupling Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Calmodulin Binding Response To Psychosocial Stress Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Mismatch Repair Regulation Of Mismatch Repair Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Membrane Raft Regulation Of Cellular Component Organization Regulation Of Cell Junction Assembly	Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity
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