AMPD1 and MYH2

Number of citations of the paper that reports this interaction (PubMedID 9730972)
0

Data Source:
HPRD (in vivo)

		AMPD1	MYH2
Description		adenosine monophosphate deaminase 1	myosin heavy chain 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Muscle Myosin Complex Cell-cell Junction Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament Protein-containing Complex Supramolecular Fiber
	Molecular Function	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	IMP Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage IMP Salvage AMP Metabolic Process	Muscle Contraction Muscle Filament Sliding
Pathways		Purine salvage	Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Autism ( 24189344) Body size at age 10 ( 32376654)
Interacting Genes		4 interacting genes: AMPD2 AMPD3 C1QTNF9 MYH2	7 interacting genes: AMPD1 DGKD DUX4L9 OBSCN PRKCE PTK2B S100A4
Entrez ID		270	4620
HPRD ID		00040	01173
Ensembl ID		ENSG00000116748	ENSG00000125414
Uniprot IDs		P23109	Q9UKX2
PDB IDs
Enriched GO Terms of Interacting Partners?		AMP Deaminase Activity IMP Salvage Deaminase Activity IMP Biosynthetic Process IMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Purine Nucleotide Salvage Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Purine Ribonucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process AMP Catabolic Process Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Podocyte Development Supramolecular Fiber Purine Nucleoside Monophosphate Catabolic Process Nucleotide Metabolic Process Muscle Myosin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process GTP Metabolic Process Myosin Filament Organophosphate Biosynthetic Process Myosin II Complex Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Microfilament Motor Activity Actin-mediated Cell Contraction Cyclic Purine Nucleotide Metabolic Process Myofibril Myosin Complex Carbohydrate Derivative Metabolic Process Cytoskeletal Motor Activity Sarcomere Actin Filament-based Movement Nucleobase-containing Compound Biosynthetic Process Organophosphate Metabolic Process Energy Homeostasis	Signaling Receptor Activator Activity Kinase Activity AMP Deaminase Activity Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Polymerization Neurotransmitter Receptor Regulator Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of B Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Monoatomic Ion Transport Phosphorylation Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Ethanol Binding Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Protein Localization To M-band Regulation Of Actin Polymerization Or Depolymerization Regulation Of Calcium Ion Transmembrane Transport Cell Activation Involved In Immune Response Regulation Of Actin Filament Length Leukocyte Activation Involved In Immune Response Positive Regulation Of Synaptic Transmission Cell Activation Activation Of Janus Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process IMP Salvage GMP Salvage Perinuclear Region Of Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Positive Regulation Of Mucus Secretion Positive Regulation Of Cytoskeleton Organization Diacylglycerol Catabolic Process Deaminase Activity NMDA Selective Glutamate Receptor Complex Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signaling Regulation Of Cell-substrate Adhesion Regulation Of Calcium Ion Transport
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