AMPD1 and AMPD2

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AMPD1	AMPD2
Name		adenosine monophosphate deaminase 1	adenosine monophosphate deaminase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol
	Molecular Function	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	IMP Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage IMP Salvage AMP Metabolic Process	IMP Biosynthetic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process IMP Salvage Cholesterol Homeostasis AMP Metabolic Process ATP Metabolic Process GTP Metabolic Process Cyclic Purine Nucleotide Metabolic Process Podocyte Development Energy Homeostasis
Pathways		Purine salvage	Purine salvage
GWAS		Autism ( 24189344 ) Body size at age 10 ( 32376654 )	Apolipoprotein B levels ( 32203549 ) Major depressive disorder ( 20125088 ) Seasonality and depression ( 30217971 )
Interacting Genes		4 interacting genes: AMPD2 AMPD3 C1QTNF9 MYH2	6 interacting genes: AMPD1 CCNDBP1 NEDD4 NTAQ1 POT1 TERF1
Entrez ID		270	271
HPRD ID		00040	11808
Ensembl ID		ENSG00000116748	ENSG00000116337
Uniprot IDs		P23109	Q01433
PDB IDs		Not available	4NO3 4NO5 8HU6 8HUB
GO Terms Enriched among Interactors		AMP Deaminase Activity IMP Salvage Deaminase Activity IMP Biosynthetic Process IMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Purine Nucleotide Salvage Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Purine Ribonucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process AMP Catabolic Process Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Podocyte Development Supramolecular Fiber Purine Nucleoside Monophosphate Catabolic Process Nucleotide Metabolic Process Muscle Myosin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process GTP Metabolic Process Myosin Filament Organophosphate Biosynthetic Process Myosin II Complex Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Microfilament Motor Activity Actin-mediated Cell Contraction Cyclic Purine Nucleotide Metabolic Process Myofibril Myosin Complex Carbohydrate Derivative Metabolic Process Cytoskeletal Motor Activity Sarcomere Actin Filament-based Movement Nucleobase-containing Compound Biosynthetic Process Organophosphate Metabolic Process Energy Homeostasis	Shelterin Complex Nuclear Telomere Cap Complex Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomeric DNA Binding Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Formation Of Structure Involved In A Symbiotic Process Positive Regulation Of Telomere Maintenance Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Chromosome Organization Positive Regulation Of Shelterin Complex Assembly Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Protein-N-terminal Glutamine Amidohydrolase Activity Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Maintenance Positive Regulation Of Chromosome Organization Channel Inhibitor Activity Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of Telomere Maintenance Positive Regulation Of Telomeric Loop Disassembly Protein-N-terminal Asparagine Amidohydrolase Activity Telomere Organization Negative Regulation Of DNA Metabolic Process AMP Deaminase Activity Phosphothreonine Residue Binding 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Telomeric D-loop Binding Telomere Assembly Chromosome, Telomeric Region IMP Salvage GMP Salvage