AMPD1 and AMPD3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		AMPD1	AMPD3
Name		adenosine monophosphate deaminase 1	adenosine monophosphate deaminase 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Region Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Identical Protein Binding Metal Ion Binding	AMP Deaminase Activity Protein Binding Hydrolase Activity Deaminase Activity Metal Ion Binding
	Biological Process	IMP Biosynthetic Process Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage IMP Salvage AMP Metabolic Process	IMP Biosynthetic Process AMP Catabolic Process Nucleoside Phosphate Metabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process IMP Salvage AMP Metabolic Process
Pathways		Purine salvage	Neutrophil degranulation Purine salvage
GWAS		Autism ( 24189344 ) Body size at age 10 ( 32376654 )	Apolipoprotein A1 levels ( 32203549 ) Appendicular lean mass ( 33097823 ) Cutaneous melanoma or hair colour ( 32341527 ) Diastolic blood pressure ( 27841878 ) Glycated hemoglobin levels ( 34059833 ) Haemorrhoidal disease ( 33888516 ) HDL cholesterol ( 24097068 20686565 ) HDL cholesterol levels ( 32203549 28334899 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin levels ( 32327693 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Neutrophil percentage of white cells ( 32888494 ) Nonunion in individuals with fractures ( 30680360 ) Pulse pressure ( 27841878 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels ( 30498476 ) Waist-hip index ( 34021172 ) White blood cell count ( 32888494 )
Interacting Genes		4 interacting genes: AMPD2 AMPD3 C1QTNF9 MYH2	2 interacting genes: AMPD1 KCNIP1
Entrez ID		270	272
HPRD ID		00040	00041
Ensembl ID		ENSG00000116748	ENSG00000133805
Uniprot IDs		P23109	Q01432
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		AMP Deaminase Activity IMP Salvage Deaminase Activity IMP Biosynthetic Process IMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process AMP Metabolic Process Purine Nucleotide Salvage Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Metabolic Process Purine Ribonucleotide Biosynthetic Process Ribose Phosphate Biosynthetic Process Purine Nucleotide Biosynthetic Process Nucleotide Biosynthetic Process Purine-containing Compound Biosynthetic Process AMP Catabolic Process Nucleoside Phosphate Biosynthetic Process Purine Ribonucleotide Metabolic Process Ribonucleotide Metabolic Process Ribose Phosphate Metabolic Process Purine Nucleotide Metabolic Process Podocyte Development Supramolecular Fiber Purine Nucleoside Monophosphate Catabolic Process Nucleotide Metabolic Process Muscle Myosin Complex Muscle Filament Sliding Actin-myosin Filament Sliding Carbohydrate Derivative Biosynthetic Process Purine-containing Compound Metabolic Process GTP Metabolic Process Myosin Filament Organophosphate Biosynthetic Process Myosin II Complex Nucleoside Phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Microfilament Motor Activity Actin-mediated Cell Contraction Cyclic Purine Nucleotide Metabolic Process Myofibril Myosin Complex Carbohydrate Derivative Metabolic Process Cytoskeletal Motor Activity Sarcomere Actin Filament-based Movement Nucleobase-containing Compound Biosynthetic Process Organophosphate Metabolic Process Energy Homeostasis	IMP Salvage AMP Deaminase Activity GMP Salvage Kv4.3-KChIP1 Channel Complex Deaminase Activity IMP Biosynthetic Process GMP Biosynthetic Process Potassium Ion Export Across Plasma Membrane IMP Metabolic Process Purine Ribonucleoside Monophosphate Biosynthetic Process GMP Metabolic Process Purine Nucleotide Salvage AMP Metabolic Process Membrane Repolarization Purine-containing Compound Salvage Ribonucleoside Monophosphate Biosynthetic Process Nucleoside Monophosphate Biosynthetic Process Potassium Channel Regulator Activity Export Across Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport Nucleoside Monophosphate Metabolic Process Potassium Channel Activity Voltage-gated Potassium Channel Complex Regulation Of Potassium Ion Transport Cytoplasmic Side Of Plasma Membrane