PABPC1 and NFX1

Number of citations of the paper that reports this interaction (PMID 17267499)
13

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		PABPC1	NFX1
Gene Name		poly(A) binding protein, cytoplasmic 1	nuclear transcription factor, X-box binding 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cytoplasmic Ribonucleoprotein Granule Extracellular Vesicular Exosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Plasma Membrane
	Molecular Function	Nucleotide Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity Poly(A) RNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Zinc Ion Binding Ligase Activity Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translation Translational Initiation Gene Expression Gene Silencing By RNA Cellular Protein Metabolic Process Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Inflammatory Response Viral Process Negative Regulation Of MHC Class II Biosynthetic Process
Pathways		Translation initiation complex formation Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Deadenylation of mRNA Translation AUF1 (hnRNP D0) destabilizes mRNA L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation-dependent mRNA decay Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Cap-dependent Translation Initiation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		43 interactors: ANAPC5 APBB1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 EIF4B EIF4G1 EIF4G3 GNB2L1 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH MAPKAPK2 NDRG1 NFX1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCSK7 PIN1 PRMT6 PXN RBM4 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	8 interactors: ELAVL4 MAML3 NUP153 NUP214 NUP62 NUP98 PABPC1 UBE2N
Entrez ID		26986	4799
HPRD ID		05247	11936
Ensembl ID		ENSG00000070756	ENSG00000086102
Uniprot IDs		E7EQV3 E7ERJ7 P11940	A0JLR2 Q12986
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process MRNA Processing Regulation Of Translation Posttranscriptional Regulation Of Gene Expression RNA Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Metabolic Process MRNA 3'-end Processing Regulation Of Protein Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Gene Expression RNA 3'-end Processing Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Translational Initiation Nitrogen Compound Metabolic Process RNA Splicing Negative Regulation Of Translation Regulation Of Gene Expression MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Metabolic Process Regulation Of Metabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Catabolic Process Viral Process Posttranscriptional Gene Silencing Regulation Of MRNA Stability Regulation Of RNA Stability Histone H3-R2 Methylation Gene Silencing By RNA Negative Regulation Of Translational Initiation Negative Regulation Of Cellular Metabolic Process Nuclear-transcribed MRNA Catabolic Process, No-go Decay Negative Regulation Of Gene Expression MRNA Stabilization Cellular Macromolecule Biosynthetic Process Negative Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing Gene Silencing By MiRNA	Mitotic Nuclear Envelope Disassembly Nuclear Envelope Disassembly Nuclear Envelope Organization Glucose Transport Hexose Transport Viral Transcription Regulation Of Glucose Transport MRNA Transport Nucleus Organization Carbohydrate Transport RNA Transport RNA Localization Cytokine-mediated Signaling Pathway Viral Life Cycle Pathogenesis Cellular Response To Cytokine Stimulus Nucleocytoplasmic Transport Nuclear Transport Response To Cytokine Nuclear Pore Complex Assembly Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nuclear Pore Organization Cellular Nitrogen Compound Metabolic Process Pore Complex Assembly RNA Metabolic Process Endomembrane System Organization Nuclear Import Nitrogen Compound Metabolic Process Gene Expression Viral Process Mitotic Cell Cycle Process Cytoplasmic Transport Mitotic Cell Cycle Membrane Organization Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Carbohydrate Metabolic Process Cell Cycle Process Macromolecule Biosynthetic Process RNA Biosynthetic Process Response To Organic Substance Cell Cycle Protein Import Into Nucleus, Docking Negative Regulation Of RNA Export From Nucleus Viral Penetration Into Host Nucleus Protein Import Into Nucleus Protein Transport Establishment Of Protein Localization
Tagcloud ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	acetylation catalytic conversely corepressor deacetylase degrading dimethylation dissociates e6 e6ap h3k4 h4 hairpin hdac histones hpv16 htert interacts keratinocytes knockdown ligase mimics msin3a papillomavirus promoter repressor shrna suppresses telomerase
Tagcloud (Difference) ?		address adhesion arm comprised coprecipitated cytoplasm cytoplasmic desmoplakin desmosomes destabilized fxr1 g3bp gain mrnas outside particles pkp1 pkp2 pkp3 plakophilins posttranscriptional regulators repeat ribonucleoprotein rnase serve stabilized unaffected upf1	acetylation catalytic conversely corepressor deacetylase degrading dimethylation dissociates e6 e6ap h3k4 h4 hairpin hdac histones hpv16 htert interacts keratinocytes knockdown ligase mimics msin3a papillomavirus promoter repressor shrna suppresses telomerase
Tagcloud (Intersection) ?