SIPA1L2 and ORC5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SIPA1L2	ORC5
Gene Name		signal-induced proliferation-associated 1 like 2	origin recognition complex, subunit 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component		Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm
	Molecular Function	GTPase Activator Activity	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways			G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS		Immunoglobulin A ( 20694011)
Protein-Protein Interactions		3 interactors: AP3M1 ORC5 TGM2	29 interactors: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 HIST3H3 HIST4H4 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4
Entrez ID		57568	5001
HPRD ID		15346	09086
Ensembl ID		ENSG00000116991	ENSG00000164815
Uniprot IDs		Q9P2F8	A4D0P7 O43913 Q53FC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Salivary Gland Cavitation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Protein Targeting To Lysosome Protein Localization To Lysosome Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Mitochondrial Calcium Ion Homeostasis Anterograde Synaptic Vesicle Transport Protein Targeting To Vacuole Establishment Of Protein Localization To Vacuole Anterograde Axon Cargo Transport Branching Involved In Salivary Gland Morphogenesis Apoptotic Cell Clearance Endoplasmic Reticulum Calcium Ion Homeostasis DNA Replication Initiation Blood Vessel Remodeling Salivary Gland Morphogenesis Peptide Cross-linking Lysosomal Transport Salivary Gland Development Axon Cargo Transport Positive Regulation Of Smooth Muscle Cell Proliferation Exocrine System Development Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Phase Transition DNA Replication Cell Cycle Phase Transition DNA-dependent DNA Replication DNA Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cell Cycle Process DNA Duplex Unwinding DNA Geometric Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Conformation Change Biosynthetic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Via Break-induced Replication Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein-DNA Complex Assembly Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Replication Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint DNA Recombination Cellular Metabolic Process Regulation Of Cell Cycle Process Response To Stress Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Epidermal Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle
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