SIPA1L2 and ORC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		SIPA1L2	ORC5
Description		signal induced proliferation associated 1 like 2	origin recognition complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm Glutamatergic Synapse	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Cytosol
	Molecular Function	GTPase Activator Activity Protein Binding	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Biological_process Regulation Of Small GTPase Mediated Signal Transduction Presynaptic Signal Transduction	DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Alzheimer's disease ( 33074286) Bipolar disorder x sex interaction ( 34099189) Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Parkinson's disease ( 25064009 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post-traumatic stress disorder ( 24677629) PR interval ( 32439900) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531) Schizophrenia ( 30285260) Smooth-surface caries ( 24556642)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		4 interacting genes: AP3M1 ORC5 TCEANC TGM2	31 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 CEBPA DBF4 DMRTA1 H3-4 H4C16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		57568	5001
HPRD ID		15346	09086
Ensembl ID		ENSG00000116991	ENSG00000164815
Uniprot IDs		A0A6Q8PH54 Q9P2F8	A4D0P7 O43913 Q53FC8
PDB IDs			5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Peptide Dopaminyltransferase Activity Histone Serotonyltransferase Activity Peptide Histaminyltransferase Activity Protein-glutamine Glutaminase Activity Peptide Noradrenalinyltransferase Activity Peptide Serotonyltransferase Activity Histone Dopaminyltransferase Activity Protein Deamination Nuclear Origin Of Replication Recognition Complex Origin Recognition Complex Dopamine Secretion Cellular Response To Dopamine Cellular Response To Serotonin Salivary Gland Cavitation Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Response To Dopamine Protein-glutamine Gamma-glutamyltransferase Activity Catecholamine Secretion Postsynaptic Recycling Endosome Clathrin-coated Vesicle Cargo Loading, AP-3-mediated Postsynaptic Neurotransmitter Receptor Internalization Regulation Of Apoptotic Cell Clearance Cellular Response To Cocaine AP-3 Adaptor Complex Branching Involved In Salivary Gland Morphogenesis Clathrin Adaptor Complex DNA Replication Origin Binding Endocytosis Peptide Cross-linking Cellular Response To Catecholamine Stimulus Anterograde Synaptic Vesicle Transport Melanosome Assembly Dopamine Transport Response To Catecholamine Mitochondrial Calcium Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Apoptotic Cell Clearance Platelet Dense Granule Organization DNA Replication Initiation Positive Regulation Of Sprouting Angiogenesis Monoamine Transport Protein Targeting To Lysosome Vesicle Cargo Loading Import Into Cell Cellular Response To Alkaloid Synaptic Vesicle Transport Melanosome Organization Chromosome Pigment Granule Organization	DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Nuclear Origin Of Replication Recognition Complex CMG Complex Origin Recognition Complex Regulation Of DNA Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Regulation Of DNA Metabolic Process DNA Repair Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Chromosome Nucleoplasm Mitotic DNA Replication Initiation DNA Damage Response Nucleus DNA Binding DNA Strand Elongation Involved In DNA Replication DNA Replication Preinitiation Complex Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle DNA Helicase Activity ATP Hydrolysis Activity Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic DNA Replication Checkpoint Signaling Nucleolus DNA Replication Factor A Complex 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Process
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