AMH and ETV5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AMH	ETV5
Description		anti-Mullerian hormone	ETS variant transcription factor 5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Nucleoplasm Plasma Membrane Synapse
	Molecular Function	Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ovarian Follicle Development Preantral Ovarian Follicle Growth Urogenital System Development Mullerian Duct Regression Cell-cell Signaling Gonadal Mesoderm Development Sex Determination Sex Differentiation Gonad Development Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Cell Differentiation Leydig Cell Differentiation Development Of Primary Male Sexual Characteristics Positive Regulation Of SMAD Protein Signal Transduction Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Neuromuscular Synaptic Transmission Locomotory Behavior Cell Differentiation Cellular Response To Oxidative Stress Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Regulation Of Synapse Organization Positive Regulation Of Glial Cell Proliferation Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Signaling by BMP Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism	Prostate cancer
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 26390057 27618447 30487518)	Adult body size ( 32376654) Bipolar disorder or body mass index ( 31754094) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 19079260 20935630 29381148 23563607 28892062 25673413 28552196 26961502 28448500) Body mass index (adult) ( 28430825) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index and HDL-C (pairwise) ( 33619380) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body size at age 10 ( 32376654) Creatinine levels ( 29124443) Estimated glomerular filtration rate ( 31451708 31152163 30604766 29124443) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29083408) Hip circumference ( 25673412) Hyperuricemia ( 29124443) Liver enzyme levels (alanine transaminase) ( 33972514) Menarche (age at onset) ( 27182965 21102462) Obesity ( 23563607) Platelet distribution width ( 32888494) Serum uric acid levels ( 29124443) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		6 interacting genes: AMHR2 ARL8B EGFR ETV5 PCSK5 ZMAT2	14 interacting genes: AMH APP AR BRCA1 CCR5 CHD3 CISH CYP3A5 DHRS7 GRAP2 HOXD9 MFHAS1 SEZ6L2 SLC22A2
Entrez ID		268	2119
HPRD ID		02979	09035
Ensembl ID		ENSG00000104899	ENSG00000244405
Uniprot IDs		P03971	P41161
PDB IDs		7L0J	4UNO 5ILV
Enriched GO Terms of Interacting Partners?		Mullerian Duct Regression Anti-Mullerian Hormone Receptor Signaling Pathway Anti-Mullerian Hormone Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Biological Process Involved In Interaction With Host Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Male Germ-line Stem Cell Asymmetric Division Viral Life Cycle Cytokine Precursor Processing Renin Secretion Into Blood Stream Viral Process Calcium Ion Regulated Lysosome Exocytosis Cytolytic Granule Membrane Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Protein Localization To Early Endosome Viral Exocytosis Skeletal System Development	Leydig Cell Differentiation Adult Locomotory Behavior Cell-cell Signaling Cell Communication Sex Determination Signaling Low-density Lipoprotein Particle Receptor Binding Adult Behavior Positive Regulation Of Receptor Internalization Negative Regulation Of Protein Localization To Nucleus Amyloid-beta Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Intracellular Signal Transduction Regulation Of Toll-like Receptor Signaling Pathway Regulation Of Response To Calcium Ion Amylin Binding Negative Regulation Of Protein Localization Positive Regulation Of Toll Signaling Pathway Locomotory Behavior Prostate Induction Regulation Of Intracellular Estrogen Receptor Signaling Pathway Male Somatic Sex Determination Centrosome Cycle Retinol Metabolic Process Developmental Growth Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development Mullerian Duct Regression Development Of Primary Male Sexual Characteristics Preantral Ovarian Follicle Growth Regulation Of Ovarian Follicle Development Acetylcholine Receptor Activator Activity PTB Domain Binding Regulation Of Growth Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of RNA Biosynthetic Process Regulation Of MiRNA Transcription Axon Midline Choice Point Recognition Regulation Of MiRNA Metabolic Process Regulation Of Biological Quality Positive Regulation Of JNK Cascade Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Endothelin Production Growth Cone Filopodium
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