AMH and ARL8B

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AMH	ARL8B
Description		anti-Mullerian hormone	ARF like GTPase 8B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Lysosome Lysosomal Membrane Endosome Spindle Cytosol Cytoskeleton Membrane Axon Midbody Early Endosome Membrane Late Endosome Membrane Cell Projection Synapse Spindle Midzone Extracellular Exosome Cytolytic Granule Membrane Axon Cytoplasm
	Molecular Function	Signaling Receptor Binding Type II Transforming Growth Factor Beta Receptor Binding Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Ovarian Follicle Development Preantral Ovarian Follicle Growth Urogenital System Development Mullerian Duct Regression Cell-cell Signaling Gonadal Mesoderm Development Sex Determination Sex Differentiation Gonad Development Response To Xenobiotic Stimulus Positive Regulation Of Gene Expression Cell Differentiation Leydig Cell Differentiation Development Of Primary Male Sexual Characteristics Positive Regulation Of SMAD Protein Signal Transduction Anti-Mullerian Hormone Receptor Signaling Pathway Negative Regulation Of Ovarian Follicle Development	Plasma Membrane Repair Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Following Phagocytosis Chromosome Segregation Anterograde Axonal Transport Protein Transport Endosomal Transport Lysosome Localization Endosomal Vesicle Fusion Early Endosome To Golgi Transport Natural Killer Cell Mediated Cytotoxicity Viral Exocytosis Cell Division Autophagosome-lysosome Fusion Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Phagosome-lysosome Fusion Late Endosome To Lysosome Transport Protein Localization To Early Endosome Calcium Ion Regulated Lysosome Exocytosis
Pathways		Signaling by BMP Transcriptional regulation of testis differentiation
Drugs
Diseases		46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Pulse pressure ( 26390057 27618447 30487518)	Disc degeneration (lumbar) ( 22993228) Fulminant type 1 diabetes ( 30552108) Metabolite levels ( 23823483) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: AMHR2 ARL8B EGFR ETV5 PCSK5 ZMAT2	13 interacting genes: AMH APP ATP5MF BTN3A3 CIDEB DLEU1 RAB14 RUFY3 SLC30A8 TGFBR1 TMEM14B TUBB VPS41
Entrez ID		268	55207
HPRD ID		02979	12483
Ensembl ID		ENSG00000104899	ENSG00000134108
Uniprot IDs		P03971	Q9NVJ2
PDB IDs		7L0J	2AL7 8JC5 8JCA
Enriched GO Terms of Interacting Partners?		Mullerian Duct Regression Anti-Mullerian Hormone Receptor Signaling Pathway Anti-Mullerian Hormone Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Binding Embryonic Organ Development Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity Biological Process Involved In Interaction With Host Shc-EGFR Complex Multivesicular Body, Internal Vesicle Lumen Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Male Germ-line Stem Cell Asymmetric Division Viral Life Cycle Cytokine Precursor Processing Renin Secretion Into Blood Stream Viral Process Calcium Ion Regulated Lysosome Exocytosis Cytolytic Granule Membrane Antigen Processing And Presentation Following Phagocytosis Antigen Processing And Presentation Of Polysaccharide Antigen Via MHC Class II Endosome To Lysosome Transport Of Low-density Lipoprotein Particle Protein Localization To Early Endosome Viral Exocytosis Skeletal System Development	Type II Transforming Growth Factor Beta Receptor Binding Nuclear Envelope Lumen Golgi-associated Vesicle Endosomal Vesicle Fusion Organelle Fusion Signaling Receptor Binding Cytoplasmic Vesicle Positive Regulation Of SMAD Protein Signal Transduction System Development Membrane Raft Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Lysosome Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Protein Transport
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