AMFR and SYVN1

Number of citations of the paper that reports this interaction (PMID 19828134)
12

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AMFR	SYVN1
Gene Name		autocrine motility factor receptor, E3 ubiquitin protein ligase	synovial apoptosis inhibitor 1, synoviolin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Dendrite Growth Cone Neuronal Cell Body Protein Complex Perinuclear Region Of Cytoplasm	Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Receptor Activity Protein Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Movement Of Cell Or Subcellular Component Signal Transduction Aging Learning Or Memory ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Protein Oligomerization	In Utero Embryonic Development Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Protein Ubiquitination Protein N-linked Glycosylation Via Asparagine ER-associated Ubiquitin-dependent Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways			Hedgehog ligand biogenesis IRE1alpha activates chaperones Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease Signaling by Hedgehog XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: BAG6 CRMP1 CYP2E1 CYP3A4 DERL1 DHFR GPI HERPUD1 HTT KPNB1 SOD1 SYVN1 TOM1L1 TRIM25 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2G1 UBE2G2 UBE2K UBE2N UBE2T UBE2W UFD1L VCP	15 interactors: AMFR APP ATN1 ATP6AP1 CLU ERN1 GPR37 TP53 UBE2D2 UBE2D3 UBE2J1 UBE2U UBE2Z USP7 VCP
Entrez ID		267	84447
HPRD ID		09130	07618
Ensembl ID		ENSG00000159461	ENSG00000162298
Uniprot IDs		Q9UKV5	Q86TM6
PDB IDs		2EJS 2LVN 2LVO 2LVP 2LVQ 2LXH 2LXP 3FSH 3H8K 3TIW 4G3O
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Catabolic Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Proteasomal Protein Catabolic Process Cellular Metabolic Process Cellular Response To Stress Protein K11-linked Ubiquitination Cellular Protein Metabolic Process Response To Endoplasmic Reticulum Stress Response To Stress Protein K63-linked Ubiquitination Response To Organic Substance ER-associated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Response To Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Apoptotic Process Toll-like Receptor Signaling Pathway Programmed Cell Death Cell Death Death Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Retrograde Protein Transport, ER To Cytosol Response To Unfolded Protein Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Monoterpenoid Metabolic Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Apoptotic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process Programmed Cell Death Protein Polyubiquitination Cell Death Death Cellular Macromolecule Catabolic Process ER-nucleus Signaling Pathway Cellular Response To Stress ER-associated Ubiquitin-dependent Protein Catabolic Process Response To Endoplasmic Reticulum Stress Cellular Protein Modification Process Cellular Protein Metabolic Process Neuron Apoptotic Process Response To Stress Neuron Death Proteolysis DNA Repair Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Hypoxia Cellular Response To Unfolded Protein Cellular Response To Decreased Oxygen Levels Cellular Response To Stimulus Cellular Response To Oxygen Levels Cellular Response To Topologically Incorrect Protein Catabolic Process Protein Metabolic Process Cellular Metabolic Process Response To Unfolded Protein Regulation Of Phosphorylation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To DNA Damage Stimulus Positive Regulation Of Phosphorylation Regulation Of Protein Oligomerization Release Of Cytochrome C From Mitochondria Regulation Of Phosphorus Metabolic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Signal Transduction Protein K48-linked Ubiquitination Metabolic Process DNA Metabolic Process
Tagcloud ?		anchoring catalyzed dnas e3 eris facilitating herpes hsv insig1 interacted k27 ligase microbial microsomes missing mita mpys perinuclear platform polyubiquitination recruiting revealing served simplex stimulator sting tank tbk1 uncovers	array asd autism betulinic cortical div e16 e3 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin ligase lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology polyubiquitination postmortem proteasomal proteasome qrt ups
Tagcloud (Difference) ?		anchoring catalyzed dnas eris facilitating herpes hsv insig1 interacted k27 microbial microsomes missing mita mpys perinuclear platform recruiting revealing served simplex stimulator sting tank tbk1 uncovers	array asd autism betulinic cortical div e16 erad frontal gaba gabaa gabaaalpha1 gyrus lactacystin lys48 mg132 middle neurobiological neurodevelopmental neuroplasticity pathophysiology postmortem proteasomal proteasome qrt ups
Tagcloud (Intersection) ?		e3 ligase polyubiquitination