TMCO1

Description		transmembrane and coiled-coil domains 1
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GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Mitochondrial Membrane Multi-pass Translocon Complex
	Molecular Function	Calcium Channel Activity Protein Binding Ribosome Binding
	Biological Process	Ossification Monoatomic Ion Transport Calcium Ion Transport ER Overload Response Endoplasmic Reticulum Calcium Ion Homeostasis Monoatomic Ion Transmembrane Transport Calcium Ion Transmembrane Transport Multi-pass Transmembrane Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS		Glaucoma ( 31959993 21532571 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 25173105 29891935) Intraocular pressure ( 30054594 31959993 31798171 29785010 29617998 29235454 28073927 25173106 24002674 22570627) Intraocular pressure (corneal compensated) ( 30894546) Medication use (antiglaucoma preparations and miotics) ( 31015401) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Novel Interacting Genes		1 novel interacting genes: FCGR2A
Interacting Genes		1 interacting genes: AMFR
Entrez ID		54499
HPRD ID		14243
Ensembl ID		ENSG00000143183
Uniprot IDs		B7Z591 Q9UM00
PDB IDs		6W6L
Enriched GO Terms of Interacting Partners?		Regulation Of SREBP Signaling Pathway Protein Alpha-1,2-demannosylation Ubiquitin-ubiquitin Ligase Activity Endoplasmic Reticulum Mannose Trimming Protein K27-linked Ubiquitination BAT3 Complex Binding Derlin-1 Retrotranslocation Complex Acute Inflammatory Response To Antigenic Stimulus Antibody-dependent Cellular Cytotoxicity IgG Receptor Activity Hypersensitivity IgG Binding Ubiquitin-specific Protease Binding Protein Deglycosylation Endoplasmic Reticulum Quality Control Compartment Non-canonical NF-kappaB Signal Transduction Fc-gamma Receptor Signaling Pathway Inflammatory Response To Antigenic Stimulus Immunoglobulin Mediated Immune Response B Cell Mediated Immunity Fc Receptor Signaling Pathway Canonical NF-kappaB Signal Transduction Acute Inflammatory Response Endoplasmic Reticulum Unfolded Protein Response Protein Autoubiquitination Positive Regulation Of Phagocytosis Leukocyte Mediated Cytotoxicity
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