TRAPPC6A and KANK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAPPC6A	KANK4
Description		trafficking protein particle complex subunit 6A	KN motif and ankyrin repeat domains 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol TRAPP Complex TRAPPIII Protein Complex	Cytoplasm Cytosol Cytoskeleton Microtubule Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Vesicle Tethering	Negative Regulation Of Actin Filament Polymerization
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs		S-palmitoyl-L-cysteine
Diseases
GWAS		Alanine aminotransferase levels ( 33339817) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33339817) Cerebrospinal fluid AB1-42 levels ( 28247064)	Fuchs's corneal dystrophy ( 28358029) Regular attendance at a gym or sports club ( 29970889)
Interacting Genes		47 interacting genes: BAG4 CAVIN2 CD2BP2 CRYAB CTDSP1 EFS EYA2 FOXN1 GGA3 GINS3 GOLGA6A GORASP2 HOXA1 HSPB8 IKZF3 INCA1 KANK4 KRTAP13-2 LHX4 MYOZ3 PAX6 PFDN5 PRR22 RAB3IP RAD54B REL RUSC1 SCOC SERTAD3 SF3B5 SMUG1 TAX1BP1 TEPSIN TRAPPC10 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC3L TRAPPC6B TRIM35 TTC23 UBAP2 YPEL3 ZFP90 ZMIZ2 ZNRD2	6 interacting genes: CSK CUL5 HAT1 HOMER3 MYLIP TRAPPC6A
Entrez ID		79090	163782
HPRD ID		14503	14109
Ensembl ID		ENSG00000007255	ENSG00000132854
Uniprot IDs		B7TZ90 O75865	B1ALP6 B3KXJ6 Q5T7N3
PDB IDs		2C0J 2J3T
Enriched GO Terms of Interacting Partners?		TRAPP Complex TRAPPII Protein Complex Vesicle Tethering Vesicle Coating TRAPPIII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Intra-Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle Organization Cis-Golgi Network Nucleus Cis-Golgi Network Membrane Negative Regulation Of Amyloid Fibril Formation	Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Lipoprotein Particle Clearance Negative Regulation Of Multicellular Organismal Process Symbiont-mediated Suppression Of Host Innate Immune Response Protein Modification Process Negative Regulation Of Focal Adhesion Disassembly G Protein-coupled Glutamate Receptor Binding Negative Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cytoplasm Negative Regulation Of Cytokine Production Negative Regulation Of Bone Resorption Protein Kinase A Catalytic Subunit Binding Regulation Of Golgi To Plasma Membrane Protein Transport Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of Cell Adhesion Negative Regulation Of Gene Expression Regulation Of Growth Hormone Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Negative Regulation Of CGAS/STING Signaling Pathway Erythropoietin-mediated Signaling Pathway Cullin-RING Ubiquitin Ligase Complex Negative Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Ubiquitin-protein Transferase Activity Internal Protein Amino Acid Acetylation Subtelomeric Heterochromatin Formation Histone H4 Acetyltransferase Activity Histone H4K12 Acetyltransferase Activity Negative Regulation Of Calcineurin-NFAT Signaling Cascade G Protein-coupled Glutamate Receptor Signaling Pathway Regulation Of Store-operated Calcium Entry Basal Part Of Cell TRAPP Complex TRAPPIII Protein Complex
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