TRAPPC6A and SF3B5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TRAPPC6A	SF3B5
Description		trafficking protein particle complex subunit 6A	splicing factor 3b subunit 5
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cis-Golgi Network Trans-Golgi Network Cytosol TRAPP Complex TRAPPIII Protein Complex	SAGA Complex Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	Protein Binding	RNA Binding Protein Binding Splicing Factor Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Vesicle Tethering	MRNA Splicing, Via Spliceosome Regulation Of DNA Repair MRNA Processing RNA Splicing Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription U2-type Prespliceosome Assembly
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
Drugs		S-palmitoyl-L-cysteine
Diseases
GWAS		Alanine aminotransferase levels ( 33339817) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Aspartate aminotransferase levels ( 33339817) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		47 interacting genes: BAG4 CAVIN2 CD2BP2 CRYAB CTDSP1 EFS EYA2 FOXN1 GGA3 GINS3 GOLGA6A GORASP2 HOXA1 HSPB8 IKZF3 INCA1 KANK4 KRTAP13-2 LHX4 MYOZ3 PAX6 PFDN5 PRR22 RAB3IP RAD54B REL RUSC1 SCOC SERTAD3 SF3B5 SMUG1 TAX1BP1 TEPSIN TRAPPC10 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC3L TRAPPC6B TRIM35 TTC23 UBAP2 YPEL3 ZFP90 ZMIZ2 ZNRD2	6 interacting genes: MIR21 MIRLET7G STAMBPL1 TRAPPC6A U2AF2 UBC
Entrez ID		79090	83443
HPRD ID		14503	18042
Ensembl ID		ENSG00000007255	ENSG00000169976
Uniprot IDs		B7TZ90 O75865	Q9BWJ5
PDB IDs		2C0J 2J3T	5IFE 5O9Z 5Z56 5Z57 5Z58 5ZYA 6AH0 6EN4 6FF4 6FF7 6QX9 6Y50 6Y5Q 7ABG 7ABH 7ABI 7B0I 7B91 7B92 7B9C 7DVQ 7EVN 7EVO 7KTS 7OMF 7ONB 7OPI 7Q3L 7Q4O 7Q4P 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8H7G 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E
Enriched GO Terms of Interacting Partners?		TRAPP Complex TRAPPII Protein Complex Vesicle Tethering Vesicle Coating TRAPPIII Protein Complex Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi Vesicle Transport COPII Vesicle Coating Intra-Golgi Vesicle-mediated Transport Golgi Apparatus Vesicle Organization Cis-Golgi Network Nucleus Cis-Golgi Network Membrane Negative Regulation Of Amyloid Fibril Formation	Poly-pyrimidine Tract Binding Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MiRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Positive Regulation Of Myofibroblast Differentiation Negative Regulation Of Interleukin-21 Production Phenotypic Switching Cellular Response To Resveratrol Negative Regulation Of Hydrogen Sulfide Biosynthetic Process Positive Regulation Of Vascular Associated Smooth Muscle Contraction Negative Regulation Of Arginine Catabolic Process Negative Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Inflammatory Response To Wounding Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Positive Regulation Of Replicative Senescence Negative Regulation Of Aortic Smooth Muscle Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Cellular Response To Hypoxia Response To Resveratrol Commitment Complex Negative Regulation Of Intracellular Signal Transduction Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Regulation Of Arginine Metabolic Process Negative Regulation Of Chondrocyte Proliferation U2AF Complex Pre-mRNA 3'-splice Site Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Rac Protein Signal Transduction Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Cell-cell Adhesion Cellular Response To Oxygen-containing Compound Retinal Cell Apoptotic Process Regulation Of Glutamine Family Amino Acid Metabolic Process Regulation Of Endothelial Tube Morphogenesis Negative Regulation Of Interleukin-1-mediated Signaling Pathway Regulation Of Myofibroblast Differentiation Cellular Response To L-leucine Metal-dependent Deubiquitinase Activity TRAPPIII Protein Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Defense Response Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Interleukin-1-mediated Signaling Pathway
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