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CFAP206 and ROCK1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
CFAP206
ROCK1
Description
cilia and flagella associated protein 206
Rho associated coiled-coil containing protein kinase 1
Image
No pdb structure
GO Annotations
Cellular Component
Radial Spoke
Cytoplasm
Cytoskeleton
Cilium
Axoneme
Motile Cilium
Ciliary Basal Body
Cell Projection
A Axonemal Microtubule
Golgi Membrane
Ruffle
Extracellular Region
Cytoplasm
Golgi Apparatus
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Stress Granule
Membrane
Lamellipodium
Bleb
Secretory Granule Lumen
Cell Projection
Schaffer Collateral - CA1 Synapse
Molecular Function
Protein Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Kinase Activity
Transferase Activity
Small GTPase Binding
Metal Ion Binding
Tau Protein Binding
Tau-protein Kinase Activity
Rho-dependent Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Biological Process
Cilium Movement
Regulation Of Cilium Beat Frequency
Sperm Axoneme Assembly
Cell Projection Organization
Axoneme Assembly
Regulation Of Flagellated Sperm Motility
Mitotic Cytokinesis
Epithelial To Mesenchymal Transition
Aortic Valve Morphogenesis
Apical Constriction
Apoptotic Process
Smooth Muscle Contraction
Leukocyte Cell-cell Adhesion
Signal Transduction
Rho Protein Signal Transduction
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Angiogenesis
Peptidyl-serine Phosphorylation
Membrane To Membrane Docking
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Regulation Of Cell Migration
Cortical Actin Cytoskeleton Organization
Actomyosin Structure Organization
Neuron Projection Development
Bleb Assembly
Negative Regulation Of Protein Binding
Regulation Of Actin Cytoskeleton Organization
Regulation Of Actin Filament-based Process
Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Keratinocyte Differentiation
Regulation Of Neuron Differentiation
Positive Regulation Of Phosphate Metabolic Process
Embryonic Morphogenesis
Leukocyte Migration
Leukocyte Tethering Or Rolling
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Myoblast Migration
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Focal Adhesion Assembly
MRNA Destabilization
Negative Regulation Of Biomineral Tissue Development
Regulation Of Microtubule Cytoskeleton Organization
Response To Transforming Growth Factor Beta
Protein Localization To Plasma Membrane
Regulation Of Synapse Maturation
Podocyte Cell Migration
Motor Neuron Apoptotic Process
Blood Vessel Diameter Maintenance
Regulation Of Angiotensin-activated Signaling Pathway
Neuron Projection Arborization
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cell Junction Assembly
Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Connective Tissue Replacement
Response To Angiotensin
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Negative Regulation Of Motor Neuron Apoptotic Process
Pathways
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
Neutrophil degranulation
RHOA GTPase cycle
RHOB GTPase cycle
RHOC GTPase cycle
RHOH GTPase cycle
RHOBTB1 GTPase cycle
Potential therapeutics for SARS
RND3 GTPase cycle
Drugs
Hydroxyfasudil
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
Fasudil
Y-27632
Ripasudil
Netarsudil
Belumosudil
Diseases
GWAS
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Lysophosphatidylcholine levels (
31551469
)
Telomere length (
30185882
)
Interacting Genes
64 interacting genes:
ADAMTSL4
ANKRD55
APIP
ATPAF2
BANP
BLZF1
C1orf94
C9orf153
CCDC33
CDX2
CEP57L1
CFP
CPSF7
CRX
CYSRT1
DISC1
EIF4ENIF1
GFAP
GLYR1
GPRASP2
GSE1
HOMEZ
IHO1
IKZF3
KIAA1328
KLHL3
KRT31
KRT34
KRT40
KRT75
KRT76
KRTAP13-1
KRTAP26-1
LZTS2
MAGED1
MDFI
MEOX2
MIF4GD
NME4
PIH1D2
PRDM16
PSMA1
PSMC5
REL
RNF138
ROCK1
SAMD3
SAXO1
SORBS3
SOX30
TADA2B
TASOR2
TCF12
TEKT1
TFIP11
TLE5
TMCC2
TRIM27
TRIM54
UBXN11
USHBP1
VPS52
ZBTB32
ZNF511
40 interacting genes:
ADD1
ARHGAP24
CASP3
CASP7
CDC25A
CDC34
CFAP206
CRMP1
DES
DPYSL2
EZR
FAM124A
GFAP
HMGB2
IKBKB
IRS1
ITSN2
LIMK1
LIMK2
LINC00452
LMO2
MAGEB4
MLC1
MSN
PFN2
POLR3C
PPP1R12A
PTK2
RDX
RHOA
RHOB
RHOC
RND3
SMAD2
SMAD5
TPPP
TRIM15
TSG101
UBE2T
VIM
Entrez ID
154313
6093
HPRD ID
12863
03414
Ensembl ID
ENSG00000272514
ENSG00000067900
Uniprot IDs
Q8IYR0
Q8N771
Q13464
PDB IDs
1S1C
2ESM
2ETK
2ETR
2V55
3D9V
3NCZ
3NDM
3O0Z
3TV7
3TWJ
3V8S
4L2W
4W7P
4YVC
4YVE
5BML
5F5P
5HVU
5KKS
5KKT
5UZJ
5WNE
5WNF
5WNG
5WNH
6E9W
7JOU
7S25
7S26
8P0S
8ZH5
Enriched GO Terms of Interacting Partners
?
Keratin Filament
Intermediate Filament
Intermediate Filament Organization
Intermediate Filament-based Process
Intermediate Filament Cytoskeleton Organization
Structural Constituent Of Skin Epidermis
Protein Binding
Structural Molecule Activity
Focal Adhesion
Cytoskeleton
Supramolecular Fiber Organization
Regulation Of Cellular Component Organization
Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Cytoplasm
Cytosol
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Protein Localization To Early Endosome
Regulation Of Organelle Organization
Astral Microtubule Organization
Regulation Of Actin Filament-based Process
Actin Filament Organization
Positive Regulation Of Protein Localization To Endosome
Negative Regulation Of Cell Projection Organization
Regulation Of Protein-containing Complex Assembly
Skeletal Muscle Satellite Cell Migration
Positive Regulation Of Stress Fiber Assembly
Cleavage Furrow
Establishment Of Epithelial Cell Apical/basal Polarity
Protein Kinase Binding
Regulation Of Establishment Of Endothelial Barrier
Regulation Of Early Endosome To Late Endosome Transport
Positive Regulation Of Actin Filament Bundle Assembly
Actin Filament Bundle Assembly
Cytoplasmic Microtubule Organization
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Actin Filament Bundle Organization
Actin Cytoskeleton Organization
Developmental Process
Establishment Of Apical/basal Cell Polarity
Regulation Of Cell Projection Organization
Intracellular Signaling Cassette
Polarized Epithelial Cell Differentiation
Cytoskeletal Protein Binding
Establishment Of Monopolar Cell Polarity
Establishment Or Maintenance Of Monopolar Cell Polarity
Regulation Of Cellular Component Size
Regulation Of Organelle Assembly
Negative Regulation Of Cellular Component Organization
Regulation Of Actin Filament Organization
Cellular Developmental Process
Cellular Response To Staurosporine
Cell Differentiation
Actin Filament-based Process
Wound Healing, Spreading Of Cells
Establishment Of Epithelial Cell Polarity
Regulation Of Adherens Junction Organization
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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