KLHL32 and CRX

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KLHL32	CRX
Description		kelch like family member 32	cone-rod homeobox
Image		No pdb structure
GO Annotations	Cellular Component		Chromatin Nucleus Transcription Regulator Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Receptor Binding Leucine Zipper Domain Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process		Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Visual Perception Animal Organ Morphogenesis Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Retina Development In Camera-type Eye
Pathways
Drugs
Diseases			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Blood pressure ( 24954895) Body mass index ( 23583978) Body mass index (adult) ( 28430825) Metabolite levels ( 23823483) Multiple sclerosis (OCB status) ( 23785401) Post bronchodilator FEV1 in COPD ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Stroke ( 32693751) Walking pace ( 33128006)	DHEAS levels ( 34748635) Serum metabolite levels ( 33031748)
Interacting Genes		9 interacting genes: APP C1orf94 CRX MEOX2 NUP62 PARVG REL SPAG8 TCF4	111 interacting genes: AASDHPPT ABI2 ACBD4 AIRIM ARIH2 ATG12 ATM ATP6V0D2 ATXN1 ATXN7 BANF1 BANF2 BANP BOD1L2 C19orf25 C1orf50 C1orf56 C9orf72 CA8 CCNC CDKN2C CFAP206 CIMIP4 CREBBP CSNK1G2-AS1 CTNNA3 DELE1 EIF5A EP300 FAAP20 FOXH1 GCM2 GLIS2 GUCD1 GYS1 HGS HNF1B IGFN1 IPO13 IRX6 KANK2 KAT2A KLHL32 LARP4 LGALS3 LIMS3 LIMS4 LNX1 LONRF1 M1AP MDFI MLLT6 MYO15B MYOZ1 NEIL2 NFYC NIP7 NPAS2 NR2E3 NRL NTF4 OR6B1 OSGIN1 OSTF1 PDC PICALM PID1 PNMA6A POGZ PPP1R16B PRKAB2 PRKN PRR35 PSMA1 PSMB10 PSMF1 QRICH1 RAX2 RBFOX1 RBPMS RHOXF2 ROR2 SAE1 SDCBP SEC14L4 SFI1 SMAD3 SMAP1 SMAP2 SMUG1 SOX10 SOX14 SOX3 SOX5 SPG21 STK16 SUFU SUOX SZT2 TBX6 TCF7L2 TFG TLX3 TNS2 UBXN2B UBXN7 VPS37C ZC3H10 ZIC1 ZNF483 ZNF688
Entrez ID		114792	1406
HPRD ID		13898	03748
Ensembl ID		ENSG00000186231	ENSG00000105392
Uniprot IDs		A0A087WYQ8 Q6IQ08 Q96NJ5	O43186
PDB IDs			9B8U
Enriched GO Terms of Interacting Partners?		PTB Domain Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity Positive Regulation Of Neuron Differentiation Lipoprotein Particle Positive Regulation Of Protein Import RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Beta-catenin-TCF7L2 Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling NF-kappaB Complex TFIIB-class Transcription Factor Binding Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape DNA Binding Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Histone H3K18 Acetyltransferase Activity Chromatin Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA Binding Protein Binding Nucleus Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cytoplasm Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Regulator Complex Histone H3K27 Acetyltransferase Activity Positive Regulation Of Protein Localization To Nucleus Beta-catenin Binding Ubiquitin Binding Central Nervous System Development Pattern Specification Process Peptidyl-lysine Acetylation Regulation Of Protein Localization To Nucleus Macroautophagy DNA-binding Transcription Factor Activity Regulation Of Gene Expression Promoter-specific Chromatin Binding Regulation Of Cellular Response To Heat N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Regulation Of Primary Metabolic Process Developmental Growth Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Acetyltransferase Activity Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gluconeogenesis Regulation Of Exosomal Secretion Somitogenesis Proteasome Core Complex
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