PPP6C and NFKBIE

Number of citations of the paper that reports this interaction (PubMedID 14743216)
0

Data Source:
HPRD (in vitro, in vivo)

		PPP6C	NFKBIE
Description		protein phosphatase 6 catalytic subunit	NFKB inhibitor epsilon
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Fibrillar Center Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding	Protein Binding Protein Sequestering Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Immune System Process Protein Dephosphorylation Innate Immune Response COPII Vesicle Coating CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		Telomere Extension By Telomerase COPII-mediated vesicle transport	Activation of NF-kappaB in B cells
Drugs
Diseases			Hodgkin lymphoma
GWAS		Pulse pressure ( 27841878) Refractive error ( 32231278) Systolic blood pressure ( 27841878 30578418)	Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Rheumatoid arthritis ( 22446963 23028356 24390342 30423114 32723749)
Interacting Genes		7 interacting genes: AURKA IGBP1 NFKBIE TGFBR1 TIPRL VAC14 ZNRF2	15 interacting genes: ANKHD1 C1QBP CUL1 HDAC4 HDAC5 IL1A JUP KBTBD7 NCOR2 NFKB1 NFKB2 PPP6C REL RELA SKP1
Entrez ID		5537	4794
HPRD ID		02141	05181
Ensembl ID		ENSG00000119414	ENSG00000146232
Uniprot IDs		A0A024R861 O00743	O00221 Q7LC14 Q96F31
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-serine Phosphorylation	Non-canonical NF-kappaB Signal Transduction Defense Response Response To External Biotic Stimulus NF-kappaB P50/p65 Complex Canonical NF-kappaB Signal Transduction Immune System Process I-kappaB/NF-kappaB Complex Immune Response Innate Immune Response NF-kappaB Complex Histone Deacetylase Binding Defense Response To Symbiont Defense Response To Other Organism Response To Lipopolysaccharide Cytosol Inflammatory Response Response To Molecule Of Bacterial Origin Cellular Response To Nicotine Ubiquitin Ligase Complex Scaffold Activity Cellular Response To Lipopolysaccharide Regulation Of Interleukin-12 Production Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of Transcription By RNA Polymerase II Response To Stress Cellular Response To Molecule Of Bacterial Origin Protein Lysine Deacetylase Activity Actinin Binding Nucleoplasm Tissue Remodeling Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Angiotensin Regulation Of MiRNA Metabolic Process Cellular Response To Interleukin-6 Negative Regulation Of Interleukin-12 Production Negative Regulation Of Myotube Differentiation Response To Other Organism Histone Deacetylase Activity Transcription Cis-regulatory Region Binding Response To Interleukin-6 Regulation Of Transcription By RNA Polymerase II Response To Lipid Protein K48-linked Ubiquitination Nucleus Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Protein Sumoylation DNA-binding Transcription Activator Activity Response To Angiotensin Response To Cytokine Response To Muscle Stretch
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