ZNF250 and ZNF639

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF250	ZNF639
Description		zinc finger protein 250	zinc finger protein 639
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Growth Host-mediated Suppression Of Viral Transcription Host-mediated Activation Of Viral Transcription Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell
Pathways		Generic Transcription Pathway
Drugs
Diseases
GWAS		Logical memory (immediate recall) in normal cognition ( 29274321)	Gout (normal type) ( 32238385) Response to antidepressants (symptom improvement) ( 29160301)
Interacting Genes		110 interacting genes: ANKRD50 APOBEC3C BEGAIN CARD10 CARD9 CBY2 CCDC102B CCDC125 CCDC136 CCDC6 CCDC85B CDCA7L CDR2 CDR2L CEP44 CEP63 CEP70 DPPA2 DRC3 DRC4 DVL2 FAM124A FAM161A FDXACB1 FHL5 GMCL1 GMNN GNPTAB GOLGA2 GOLGA6L9 GRAP2 GRIPAP1 GUCD1 HEXIM2 HMBOX1 HOMEZ HOOK1 HOOK2 HSF2BP KASH5 KIFC3 KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 LDOC1 LMO2 LZTS1 LZTS2 MAGOHB MEOX2 MID2 MTUS2 MYF5 NDEL1 NEXN NINL NXF1 PIBF1 PICK1 PLEKHF2 PRDM14 PRPF31 RUBCN RUNDC3A SPECC1L SPRED2 SSX2IP STX1A SYNE4 TFF1 TMCC2 TNK1 TNNT1 TNS2 TOP3B TRAF1 TRAF2 TRIM23 TRIM27 TRIM41 TRIM54 UBE3A YJU2B ZBTB43 ZBTB6 ZBTB8A ZC4H2 ZCCHC13 ZCCHC7 ZFP1 ZNF165 ZNF175 ZNF202 ZNF330 ZNF345 ZNF460 ZNF473 ZNF547 ZNF57 ZNF572 ZNF639 ZNF648 ZNF668 ZNF768 ZNF792 ZNF837 ZRANB1	12 interacting genes: APTX CREBBP CRYAA MCRS1 MPP1 PNKP PRPF18 RIN3 ZBTB24 ZNF250 ZNF792 ZNF837
Entrez ID		58500	51193
HPRD ID		15758	15882
Ensembl ID		ENSG00000196150	ENSG00000121864
Uniprot IDs		B3KNS9 P15622	Q9UID6
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Zinc Ion Binding Identical Protein Binding Microtubule Binding Cytoskeleton Microtubule Regulation Of RNA Biosynthetic Process Centrosome Keratin Filament Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Metal Ion Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Microtubule-based Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Response To Muramyl Dipeptide CBM Complex FHF Complex Cytoskeleton Organization Intermediate Filament	Polynucleotide 3'-phosphatase Activity Damaged DNA Binding Positive Regulation Of DNA Repair Histone Acetyltransferase Complex DNA Repair Regulation Of DNA Repair U2-type Post-spliceosomal Complex DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Negative Regulation Of Mast Cell Chemotaxis Positive Regulation Of DNA Metabolic Process Zinc Ion Binding DNA Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Generation Of Catalytic Spliceosome For Second Transesterification Step Positive Regulation Of Telomere Maintenance ATP-dependent Polynucleotide 5'-hydroxyl-kinase Activity Phosphoglycolate Phosphatase Activity Positive Regulation Of Double-strand Break Repair Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation DNA Damage Response Regulation Of Protein Stability Positive Regulation Of Protein Localization To Nucleus Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity MRF Binding Response To Radiation Regulation Of Transcription By RNA Polymerase II Centriolar Satellite RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Purine Nucleotide Binding Double-stranded DNA Binding Positive Regulation Of Protein Localization To Nucleolus Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Response To UV Metal Ion Binding Regulation Of Protein Localization To Nucleus Lens Fiber Cell Morphogenesis Poly(G) Binding Telomerase Inhibitor Activity G-quadruplex RNA Binding Regulation Of Mast Cell Chemotaxis
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