GIGYF2 and GRB10

Number of citations of the paper that reports this interaction (PMID 12771153)
14

Data Source:
HPRD (two hybrid)

		GIGYF2	GRB10
Gene Name		GRB10 interacting GYF protein 2	growth factor receptor-bound protein 10
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Membrane	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Poly(A) RNA Binding	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding
	Biological Process	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Multicellular Organism Growth Cellular Protein Metabolic Process Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance	Insulin Receptor Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Insulin Negative Regulation Of Phosphorylation Positive Regulation Of Phosphorylation Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events SHC activation Signaling by Insulin receptor
Drugs
Diseases
GWAS			Acute lymphoblastic leukemia (childhood) ( 23512250) Bone mineral density ( 22504420) Fasting glucose-related traits (interaction with BMI) ( 22581228) Systemic sclerosis ( 21779181)
Protein-Protein Interactions		6 interactors: APC GRB10 RBM12 RQCD1 SNRPB WBP11	30 interactors: ABL1 AKT1 APP BCR DOK1 EGFR ELK1 EPHB1 FYN GHR GIGYF1 GIGYF2 IGF1R INSR IRS1 JAK2 KDR KIT MAP2K1 MAP3K14 MAPK1 MEGF10 NEDD4 NOA1 PDGFRB RAF1 RET RQCD1 SRC ZDHHC17
Entrez ID		26058	2887
HPRD ID		11639	03312
Ensembl ID		ENSG00000204120	ENSG00000106070
Uniprot IDs		Q6Y7W6	Q13322
PDB IDs			1NRV 3HK0
Enriched GO Terms of Interacting Partners?		MRNA Processing MRNA Metabolic Process MRNA 3'-end Processing RNA Processing RNA 3'-end Processing Positive Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Odontogenesis Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Metaphase/anaphase Transition Of Mitotic Cell Cycle Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Regulation Of Wnt Signaling Pathway Ribonucleoprotein Complex Biogenesis RNA Splicing Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Microtubule Polymerization Positive Regulation Of Pseudopodium Assembly Negative Regulation Of Phosphorylation Negative Regulation Of Glucose Transport Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway NcRNA Metabolic Process Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Attachment Of Spindle Microtubules To Kinetochore Histone MRNA Metabolic Process Regulation Of Intracellular Estrogen Receptor Signaling Pathway Muscle Cell Cellular Homeostasis Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Microtubule Polymerization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Odontogenesis Negative Regulation Of Microtubule Depolymerization Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Glycogen Biosynthetic Process Mitotic Spindle Assembly Checkpoint Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Spindle Assembly Checkpoint Cytoplasmic Microtubule Organization Regulation Of Glycogen Metabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway Mitotic Spindle Checkpoint Termination Of RNA Polymerase II Transcription Mitotic Cytokinesis Spliceosomal SnRNP Assembly Negative Regulation Of Chromosome Segregation	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of Cell Motility Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Locomotion Regulation Of Cellular Component Movement Phosphorylation Cellular Response To Organic Substance Intracellular Signal Transduction Cellular Response To Hormone Stimulus Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Migration ERBB Signaling Pathway Positive Regulation Of Cell Motility Peptidyl-amino Acid Modification Cellular Response To Organonitrogen Compound Positive Regulation Of Cellular Component Movement Signal Transduction Positive Regulation Of Locomotion Regulation Of Signaling Regulation Of Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Response To Organic Substance Signaling Regulation Of Protein Metabolic Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Communication Cellular Response To Peptide Neurotrophin Signaling Pathway Regulation Of Protein Kinase Activity Response To Hormone Regulation Of Cell Migration Fibroblast Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Fc Receptor Signaling Pathway
Tagcloud ?		aberrant alter ameliorated cognitive contrary correspondingly diabetes erk1 exhibits functionally grb10 heterozygous hippocampus histopathological igf1r impairment interacting neurobehavioral neurodegeneration neuropathogenic obvious phsophorylation regulating reversed streptozotocin stz trafficking ultrastructural	becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights interacting looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Difference) ?		aberrant alter ameliorated cognitive contrary correspondingly diabetes erk1 exhibits functionally heterozygous hippocampus histopathological igf1r impairment neurobehavioral neurodegeneration neuropathogenic obvious phsophorylation regulating reversed streptozotocin stz trafficking ultrastructural	becomes carries cytokine driven effector emerging exert fashion fos grbir homology hybrid insights looked member nonreceptor obscure phosphorylated pleckstrin profoundly ptks subfamily subset suppresses syk tec tips turned
Tagcloud (Intersection) ?		grb10 interacting