GIGYF2 and CNOT9

Number of citations of the paper that reports this interaction (PubMedID 29395067)
0

Data Source:
BioGRID (proximity labelling technology, affinity chromatography technology, pull down)

		GIGYF2	CNOT9
Description		GRB10 interacting GYF protein 2	CCR4-NOT transcription complex subunit 9
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GO Annotations	Cellular Component	Cytoplasm Endosome Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoplasmic Stress Granule Membrane Vesicle Protein-containing Complex Perikaryon Proximal Dendrite	P-body Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex Protein-containing Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding Molecular Adaptor Activity Proline-rich Region Binding	Transcription Coactivator Activity Epidermal Growth Factor Receptor Binding Protein Binding Kinase Binding Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	Feeding Behavior Adult Locomotory Behavior Post-embryonic Development Post-transcriptional Gene Silencing Negative Regulation Of Translation Spinal Cord Motor Neuron Differentiation Mitotic G1 DNA Damage Checkpoint Signaling Multicellular Organism Growth Negative Regulation Of Translational Initiation Insulin-like Growth Factor Receptor Signaling Pathway Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuromuscular Process Controlling Balance Negative Regulation Of Type I Interferon-mediated Signaling Pathway MRNA Destabilization Rescue Of Stalled Ribosome	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Catabolic Process Regulation Of Translation Sex Differentiation Negative Regulation Of Translation Cytokine-mediated Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of DNA-templated Transcription
Pathways			Deadenylation of mRNA Activation of anterior HOX genes in hindbrain development during early embryogenesis TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain M-decay: degradation of maternal mRNAs by maternally stored factors
Drugs
Diseases		Parkinson's disease (PD)
GWAS		Anxiety and stress-related disorders ( 31116379) Appendicular lean mass ( 33097823) Autism spectrum disorder or schizophrenia ( 28540026) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery disease ( 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hip circumference adjusted for BMI ( 34021172) Myocardial infarction ( 33532862) Schizophrenia ( 23974872 25056061 29483656)
Interacting Genes		12 interacting genes: APC CNOT9 CRYAA GRB10 GRB14 GRB7 RBM12 RNF10 SNRPB UBC USP7 WBP11	11 interacting genes: AKT1 EGFR GADD45A GADD45B GADD45G GIGYF1 GIGYF2 GRB10 MESD MYB OBI1
Entrez ID		26058	9125
HPRD ID		11639	08828
Ensembl ID		ENSG00000204120	ENSG00000144580
Uniprot IDs		Q6Y7W6	D5MQE1 Q92600
PDB IDs		5NVL 5NVM 7RUP	2FV2 4CRU 4CRV 4CT6 4CT7 5LSW 5ONA 5ONB 6HOM 6HON 9FL8
Enriched GO Terms of Interacting Partners?		Insulin Receptor Signaling Pathway Lens Fiber Cell Morphogenesis Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Leading Edge Membrane Cytosol Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Cytoplasm Enzyme-linked Receptor Protein Signaling Pathway Protein Methylation	Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of P38MAPK Cascade Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of P38MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Localization To Membrane Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Cycle Enzyme-linked Receptor Protein Signaling Pathway Response To UV-A Kinase Binding Positive Regulation Of JNK Cascade Protein-containing Complex Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorylation Regulation Of Apoptotic Process Regulation Of JNK Cascade Regulation Of G1/S Transition Of Mitotic Cell Cycle Embryonic Organ Development Regulation Of Programmed Cell Death Regulation Of Glycogen Biosynthetic Process Regulation Of Protein Localization To Membrane Positive Regulation Of MAPK Cascade Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Apoptotic Process Regulation Of Glycogen Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Translational Initiation Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Response To Epidermal Growth Factor Regulation Of MAPK Cascade Positive Regulation Of Fibroblast Proliferation Positive Regulation Of MiRNA Transcription Regulation Of TRNA Methylation Regulation Of D-glucose Import Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Multivesicular Body, Internal Vesicle Lumen Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Cycle G1/S Phase Transition Epidermal Growth Factor Receptor Signaling Pathway
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