ZNF521 and RARS1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZNF521	RARS1
Description		zinc finger protein 521	arginyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Exosome
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	TRNA Binding Nucleotide Binding Aminoacyl-tRNA Ligase Activity Arginine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity Arginine Binding Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Neuron Fate Commitment	Translation TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation
Pathways		RUNX2 regulates osteoblast differentiation Formation of the anterior neural plate Formation of the posterior neural plate	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Height ( 31562340) High density lipoprotein cholesterol levels ( 30498476) Mitochondrial DNA levels ( 25240745) Myeloproliferative neoplasms ( 33057200) Nickel levels ( 26025379) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Systemic juvenile idiopathic arthritis ( 27927641) Takayasu arteritis ( 25604533) Toenail selenium levels ( 25343990) Urgency urinary incontinence ( 25524241) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BRAP CFAP298 EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4	79 interacting genes: AIMP1 CDC42 CEBPA EPRS1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR25 MIR29A MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OGT QARS1 SUMO2 WBP4 ZNF521
Entrez ID		25925	5917
HPRD ID		18350	00142
Ensembl ID		ENSG00000198795	ENSG00000113643
Uniprot IDs		J3KTI4 Q8IYZ2 Q96K83	P54136
PDB IDs			4Q2T 4Q2X 4Q2Y 4R3Z 4ZAJ
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding Cardiac Conduction System Development SMAD Protein Signal Transduction Cell Fate Commitment DNA-binding Transcription Factor Activity Transcription Regulator Complex MAPK Cascade Transcription Coactivator Binding Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Embryonic Pattern Specification Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Mast Cell Secretory Granule Organization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-templated Transcription Sequence-specific DNA Binding Nucleoplasm Basophil Differentiation Male Gonad Development Regulation Of Definitive Erythrocyte Differentiation Eosinophil Fate Commitment Regulation Of Primitive Erythrocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesodermal Cell Fate Commitment Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Primitive Erythrocyte Differentiation Striated Muscle Tissue Development	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Negative Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Angiogenesis Regulation Of Metabolic Process Regulation Of Translation Regulation Of Vasculature Development Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Cytokine Production Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Process Regulation Of RNA Stability Regulation Of Endothelial Cell Migration Extracellular Space Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Cell Motility Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
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