ZNF521 and GATA1

Number of citations of the paper that reports this interaction (PMID 19049973)
6

Data Source:
HPRD (in vitro)

		ZNF521	GATA1
Gene Name		zinc finger protein 521	GATA binding protein 1 (globin transcription factor 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Transcription Factor Complex Transcriptional Repressor Complex
	Molecular Function	DNA Binding Protein Domain Specific Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding P53 Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding DNA Binding, Bending Chromatin DNA Binding Sequence-specific DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cell Differentiation	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Platelet Aggregation Transcriptional Activation By Promoter-enhancer Looping Dendritic Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998)
Protein-Protein Interactions		5 interactors: EBF1 GATA1 LYST SMAD1 SMAD4	51 interactors: AKT1 ARID1A CASP3 CCDC24 CEBPE CREBBP FBF1 FLI1 FRS3 HDAC3 HDAC4 HDAC5 HEXIM2 HEY1 HOXA1 HSPA4 KRTAP10-5 KRTAP9-2 LMO2 MAPK1 MAPK3 MAPK6 MED1 PRKAA1 PRKAB2 RADIL RAI1 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 SUMO1 TAF7 TAL1 TAX1BP3 TRIM25 TRIM29 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		25925	2623
HPRD ID		18350	02372
Ensembl ID		ENSG00000198795	ENSG00000102145
Uniprot IDs		J3KTI4 Q96K83	P15976
PDB IDs
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process BMP Signaling Pathway Embryonic Pattern Specification Wound Healing Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Response To Wounding Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Basophil Differentiation Eosinophil Fate Commitment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nephrogenic Mesenchyme Morphogenesis Mast Cell Secretory Granule Organization Kidney Epithelium Development Transcription, DNA-templated Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Eosinophil Differentiation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Transcriptional Activation By Promoter-enhancer Looping Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Ossification Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation Embryo Development Regulation Of Binding Endocardial Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Primary MiRNA Processing RNA Metabolic Process Osteoblast Fate Commitment	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Biosynthetic Process Nucleosome Disassembly Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Chromatin Organization Regulation Of Cellular Process Anatomical Structure Development Chromatin Remodeling Myeloid Cell Differentiation Chromatin Modification Cell Differentiation Multicellular Organismal Development Embryonic Organ Development Hemopoiesis Chromosome Organization Megakaryocyte Differentiation Immune System Development
Tagcloud ?			alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Difference) ?			alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Intersection) ?