RARS and QARS

Number of citations of the paper that reports this interaction (PMID 22863883)
15

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		RARS	QARS
Gene Name		arginyl-tRNA synthetase	glutaminyl-tRNA synthetase
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Vesicular Exosome	Cytoplasm Mitochondrial Matrix Cytosol
	Molecular Function	TRNA Binding Arginine-tRNA Ligase Activity Protein Binding ATP Binding Arginine Binding	Glutamine-tRNA Ligase Activity Protein Binding ATP Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation Gene Expression	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Brain Development Gene Expression
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AIMP1 EPRS QARS	37 interactors: AES ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AFX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 PIK3R3 PIN1 PRRC2A RARS RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B
Entrez ID		5917	5859
HPRD ID		00142	07223
Ensembl ID		ENSG00000113643	ENSG00000172053
Uniprot IDs		F5H3T8 P54136	B4DWJ2 B7Z840 P47897
PDB IDs
Enriched GO Terms of Interacting Partners?		Prolyl-tRNA Aminoacylation Glutamyl-tRNA Aminoacylation TRNA Aminoacylation For Protein Translation TRNA Aminoacylation TRNA Metabolic Process Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Translation Negative Regulation Of Translation Carboxylic Acid Metabolic Process Cellular Response To Interferon-gamma Organic Acid Metabolic Process Glutaminyl-tRNA Aminoacylation Response To Interferon-gamma Defense Response Regulation Of Translation Immune System Process Small Molecule Metabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Response To Cytokine Stimulus RNA Metabolic Process Response To Cytokine Response To Stress Gene Expression Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Protein Complex Assembly Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Endothelial Cell Proliferation Nitrogen Compound Metabolic Process Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Organic Substance Glucose Metabolic Process Cellular Component Assembly Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process	Regulation Of Protein Binding Regulation Of Kinase Activity Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Metabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Protein Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Regulation Of Protein Phosphorylation Regulation Of Binding Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Binding Regulation Of JNK Cascade Response To Inorganic Substance Regulation Of Phosphorus Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Protein Phosphorylation Apoptotic Process Programmed Cell Death Positive Regulation Of Transferase Activity Cell Cycle Process Metabolic Process Cell Death Death Cell Cycle Cellular Protein Modification Process Regulation Of MAPK Cascade Positive Regulation Of Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Binding Cellular Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Protein Homodimerization Activity Regulation Of Metabolic Process Response To Stimulus Innate Immune Response
Tagcloud ?		ap argue capable dimeric dimerization disrupt fos glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins raralpha repress repression responsive retinoic retinoid rxr rxrs	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured kars lysyl nerve pharmaceutical possibility powerful primers root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		ap argue capable dimeric dimerization disrupt fos glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins raralpha repress repression responsive retinoic retinoid rxr rxrs	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured kars lysyl nerve pharmaceutical possibility powerful primers root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?