ZNF521 and CFAP298

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		ZNF521	CFAP298
Description		zinc finger protein 521	cilia and flagella associated protein 298
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Cilium Ciliary Basal Body Cell Projection
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Protein Domain Specific Binding Metal Ion Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Neuron Fate Commitment	Regulation Of Cilium Movement Cilium Assembly
Pathways		RUNX2 regulates osteoblast differentiation Formation of the anterior neural plate Formation of the posterior neural plate
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Age at first sexual intercourse ( 34211149) Chronotype ( 30696823) Daytime nap ( 33568662) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Height ( 31562340) High density lipoprotein cholesterol levels ( 30498476) Mitochondrial DNA levels ( 25240745) Myeloproliferative neoplasms ( 33057200) Nickel levels ( 26025379) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Systemic juvenile idiopathic arthritis ( 27927641) Takayasu arteritis ( 25604533) Toenail selenium levels ( 25343990) Urgency urinary incontinence ( 25524241) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: BRAP CFAP298 EBF1 EIF1AD GATA1 LYST RARS1 SMAD1 SMAD4	21 interacting genes: APP COPS5 ERBB2 EWSR1 FMN2 GMCL1 KPNA4 MAPK6 NCOA2 PAX6 PTGER4 RANBP9 RFX5 RPH3A SNRNP70 SPTBN4 TAF1 TRPS1 UNC13B ZNF521 ZNF624
Entrez ID		25925	56683
HPRD ID		18350	10756
Ensembl ID		ENSG00000198795	ENSG00000159079
Uniprot IDs		J3KTI4 Q8IYZ2 Q96K83	C9J818 D3DSE6 P57076
PDB IDs
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex I-SMAD Binding Cardiac Conduction System Development SMAD Protein Signal Transduction Cell Fate Commitment DNA-binding Transcription Factor Activity Transcription Regulator Complex MAPK Cascade Transcription Coactivator Binding Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Positive Regulation Of MiRNA Metabolic Process Embryonic Pattern Specification Positive Regulation Of MiRNA Transcription Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Intracellular Iron Ion Homeostasis Negative Regulation Of Muscle Cell Differentiation Mast Cell Secretory Granule Organization DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA-templated Transcription Sequence-specific DNA Binding Nucleoplasm Basophil Differentiation Male Gonad Development Regulation Of Definitive Erythrocyte Differentiation Eosinophil Fate Commitment Regulation Of Primitive Erythrocyte Differentiation DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Mesodermal Cell Fate Commitment Regulation Of MiRNA Transcription Homomeric SMAD Protein Complex Regulation Of MiRNA Metabolic Process Stem Cell Differentiation Osteoblast Fate Commitment Transforming Growth Factor Beta Receptor Signaling Pathway BMP Signaling Pathway Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Arginyl-tRNA Aminoacylation Arginine-tRNA Ligase Activity Primitive Erythrocyte Differentiation Striated Muscle Tissue Development	Positive Regulation Of Macromolecule Metabolic Process Amyloid-beta Complex Positive Regulation Of Metabolic Process Negative Regulation Of Blood Circulation Growth Cone Lamellipodium Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Response To Calcium Ion Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Amylin Binding Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Catabolic Process Protein Heterodimerization Activity Regulation Of Metabolic Process Positive Regulation Of Amyloid Precursor Protein Catabolic Process Nucleus Axonogenesis Neuromuscular Junction Development Nucleoplasm Secretion By Cell Forebrain-midbrain Boundary Formation Pancreatic A Cell Development Transcription Coregulator Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Neuron Fate Commitment Establishment Of Organelle Localization Negative Regulation Of Eosinophil Extravasation Positive Regulation Of Androgen Receptor Signaling Pathway Transcription Regulator Inhibitor Activity Positive Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Homologous Chromosome Movement Towards Spindle Pole In Meiosis I Anaphase Chromatin Nuclear Receptor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Protein Metabolic Process Locomotory Behavior MRNA Transcription By RNA Polymerase II Establishment Of Localization In Cell Regulation Of Amyloid Precursor Protein Catabolic Process Protein-containing Complex Negative Regulation Of Macromolecule Metabolic Process
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