RARS and EPRS

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (two hybrid)

		RARS	EPRS
Gene Name		arginyl-tRNA synthetase	glutamyl-prolyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Extracellular Vesicular Exosome	Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex Ribonucleoprotein Complex GAIT Complex
	Molecular Function	TRNA Binding Arginine-tRNA Ligase Activity Protein Binding ATP Binding Arginine Binding	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding RNA Stem-loop Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Arginyl-tRNA Aminoacylation Gene Expression	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Protein Complex Assembly Gene Expression Negative Regulation Of Translation Cellular Response To Interferon-gamma
Pathways		Cytosolic tRNA aminoacylation tRNA Aminoacylation	Cytosolic tRNA aminoacylation tRNA Aminoacylation
Drugs			L-Glutamic Acid L-Proline \'5\'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5\'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine \'5\'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: AIMP1 EPRS QARS	12 interactors: AIMP2 ARL4D DUS2 EEF1D HSP90AA1 IARS NEDD4 NELFCD POU2F1 RARS SYNCRIP TAB1
Entrez ID		5917	2058
HPRD ID		00142	00703
Ensembl ID		ENSG00000113643	ENSG00000136628
Uniprot IDs		F5H3T8 P54136	P07814
PDB IDs			1FYJ 4HVC
Enriched GO Terms of Interacting Partners?		Prolyl-tRNA Aminoacylation Glutamyl-tRNA Aminoacylation TRNA Aminoacylation For Protein Translation TRNA Aminoacylation TRNA Metabolic Process Cellular Amino Acid Metabolic Process NcRNA Metabolic Process Translation Negative Regulation Of Translation Carboxylic Acid Metabolic Process Cellular Response To Interferon-gamma Organic Acid Metabolic Process Glutaminyl-tRNA Aminoacylation Response To Interferon-gamma Defense Response Regulation Of Translation Immune System Process Small Molecule Metabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Response To Cytokine Stimulus RNA Metabolic Process Response To Cytokine Response To Stress Gene Expression Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Protein Metabolic Process Protein Complex Assembly Cellular Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Immune Response Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Endothelial Cell Proliferation Nitrogen Compound Metabolic Process Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Organic Substance Glucose Metabolic Process Cellular Component Assembly Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process	TRNA Metabolic Process TRNA Aminoacylation For Protein Translation TRNA Aminoacylation RNA Metabolic Process NcRNA Metabolic Process Nitrogen Compound Metabolic Process Translation Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Respiratory System Development Nucleobase-containing Compound Metabolic Process Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Transmission Of Virus Development Involved In Symbiotic Interaction Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Isoleucyl-tRNA Aminoacylation Cellular Amino Acid Metabolic Process Metabolic Process Regulation Of Cellular Protein Metabolic Process Protein Import Into Mitochondrial Outer Membrane Osteoblast Differentiation Viral Process Negative Regulation Of Cellular Metabolic Process CRD-mediated MRNA Stabilization Arginyl-tRNA Aminoacylation Progesterone Receptor Signaling Pathway Olfactory Placode Formation Immune Response Negative Regulation Of Gene Expression Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Type II Pneumocyte Differentiation Negative Regulation Of Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Glucocorticoid Receptor Signaling Pathway Activation Of MAPKKK Activity Intracellular Receptor Signaling Pathway Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Lens Induction In Camera-type Eye Macromolecule Biosynthetic Process Heart Morphogenesis Positive Regulation Of Cellular Metabolic Process Protein Targeting To Lysosome Negative Regulation Of Sodium Ion Transport
Tagcloud ?		ap argue capable dimeric dimerization disrupt fos glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins raralpha repress repression responsive retinoic retinoid rxr rxrs	adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Difference) ?		ap argue capable dimeric dimerization disrupt fos glucocorticoid heterodimerization homo homodimerization hraralpha hybrid indirect interfere jun liganded occurring promoters protooncoproteins raralpha repress repression responsive retinoic retinoid rxr rxrs	adequate analgesic analgesics assessments caution codeine comparative documentation dying electronic feasible healthcare hospitalised instrument intensity interpretation limitation morphine norwegian old oldest pain palliative paracetamol regard resident retrospective workers young
Tagcloud (Intersection) ?