CCDC28A and IGFBP6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		CCDC28A	IGFBP6
Name		coiled-coil domain containing 28A	insulin like growth factor binding protein 6
Structure		No pdb structure
GO Annotations	Cellular Component	None	Extracellular Region Extracellular Space Insulin-like Growth Factor Binary Complex
	Molecular Function	Protein Binding	Fibronectin Binding Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Identical Protein Binding
	Biological Process	None	Signal Transduction Negative Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		None	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
GWAS		No GWAS studies recorded	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 )
Novel Interactors		None recorded	2 novel interactors: DDX10 ERBB3
Interacting Genes		9 interacting genes: DYNLL1 ICA1 IGFBP6 KIFC3 KRTAP9-2 MYOG SRPK2 TRIM54 USHBP1	38 interacting genes: ALPP ANKRD11 AQP1 C1orf74 CCDC116 CCDC28A CDIPT CREB5 DRC4 EFEMP1 EFEMP2 ENKD1 EPDR1 GET3 IGF1 IGF2 KRTAP10-8 KRTAP5-7 KRTAP5-9 MBD3 MEIS2 MSGN1 MYCBP2 NCALD PLEKHA7 POU4F2 RABGGTB RANBP10 SDCBP SGTA SMCP TF UBAC1 UBQLN1 UBQLN2 UBQLN4 ZNF417 ZNF587
Entrez ID		25901	3489
HPRD ID		09857	00902
Ensembl ID		ENSG00000024862	ENSG00000167779
Uniprot IDs		B4DUJ5 Q8IWP9	F8VVA5 P24592
PDB IDs		Not available	1RMJ 2JM2
GO Terms Enriched among Interactors		None	Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Exocrine Pancreas Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Axon Guidance